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Molecule Parameter List for CaMK-thr305 | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | AMPAR_traff_
model0 | 59 | Network |
Shared_Object_AMPAR_traff_model0, CaMKII, CaM,
PP1, PP2B, PP1_PSD,
PKA, AC, AMPAR,
AMPAR_memb | | This is model 0 from Hayer and Bhalla, PLoS Comput Biol 2005. It has a bistable model of AMPAR traffick, plus a
non-bistable model of CaMKII. This differs from the reference model (model 1) in that model0 lacks degradation and turno
ver reactions for AMPAR. |
CaMK-thr305 acting as a Molecule in AMPAR_traff_model0 Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | CaMK-thr305 | AMPAR_traff_
model0
Accession No. : 59 | CaMKII
Pathway No. : 235 | 0 | 0.09 | No | | This forms due to basal autophosphorylation, but I think it has to be considered as a pathway even if some CaM is floating around. In either case it will tend to block further binding of CaM, and will not display any enzyme activity. See Hanson and Schulman JBC 267:24 pp17216-17224 1992 |
CaMK-thr305 acting as a Summed Molecule in AMPAR_traff_model0 Network
CaMK-thr305 acting as a Substrate for an Enzyme in AMPAR_traff_model0 Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | PP1-active /
Deph-thr305a | AMPAR_traff_
model0
Accession No. : 59 | PP1
Pathway No. : 237 | 5.09905 | 2.5 | 4 | explicit E-S complex | Substrate
CaMK-thr305
Product
CaMKII
|
CaMK-thr305 acting as a Product of an Enzyme in AMPAR_traff_model0 Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | PP1-active /
Deph-thr286c | AMPAR_traff_
model0
Accession No. : 59 | PP1
Pathway No. : 237 | 5.09905 | 2.5 | 4 | explicit E-S complex | Substrate
CaMKII***
Product
CaMK-thr305
|
CaMK-thr305 acting as a Product in a reaction in AMPAR_traff_model0 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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