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Molecule Parameter List for CaMK-thr305

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

CaMK-thr305 participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	1	0	1	1	0	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
AMPAR_traff_ model0	59	Network	Shared_Object_AMPAR_traff_model0,  CaMKII,  CaM,   PP1,  PP2B,  PP1_PSD,   PKA,  AC,  AMPAR,   AMPAR_memb
This is model 0 from Hayer and Bhalla, PLoS Comput Biol 2005. It has a bistable model of AMPAR traffick, plus a non-bistable model of CaMKII. This differs from the reference model (model 1) in that model0 lacks degradation and turno ver reactions for AMPAR.

CaMK-thr305 acting as a Molecule in  AMPAR_traff_model0 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CaMK-thr305	AMPAR_traff_ model0 Accession No. : 59	CaMKII Pathway No. : 235	0	0.09	No
This forms due to basal autophosphorylation, but I think it has to be considered as a pathway even if some CaM is floating around. In either case it will tend to block further binding of CaM, and will not display any enzyme activity. See Hanson and Schulman JBC 267:24 pp17216-17224 1992

CaMK-thr305 acting as a Summed Molecule in  AMPAR_traff_model0 Network

Accession Name	Pathway Name	Target	Input
AMPAR_traff_ model0 Accession No. : 59	CaMKII Pathway No. : 235	tot_CaMKII_cyt	CaMKII-CaM CaMKII-thr286*-C aM CaMKII-thr286 CaMKII*** CaMK-thr305 CaMKII basal_CaMKII_ cyt

CaMK-thr305 acting as a Substrate for an Enzyme in  AMPAR_traff_model0 Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
PP1-active  / Deph-thr305a	AMPAR_traff_ model0 Accession No. : 59	PP1 Pathway No. : 237	5.09905	2.5	4	explicit E-S complex	Substrate CaMK-thr305 Product CaMKII

CaMK-thr305 acting as a Product of an Enzyme in  AMPAR_traff_model0 Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
PP1-active  / Deph-thr286c	AMPAR_traff_ model0 Accession No. : 59	PP1 Pathway No. : 237	5.09905	2.5	4	explicit E-S complex	Substrate CaMKII*** Product CaMK-thr305

CaMK-thr305 acting as a Product in a reaction in  AMPAR_traff_model0 Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
back_2	AMPAR_traff_ model0 Accession No. : 59	CaMKII Pathway No. : 235	0.3 (s^-1)	0 (#^-1 s^-1)	Not applicable**	-	Substrate CaMKII-thr305-PS D Product CaMK-thr305 NMDAR
Same as for back_1

** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration