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Molecule Parameter List for tot_CaM_CaMKII

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

tot_CaM_CaMKII participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	2	2	0	0	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
AMPAR_traff_ model0	59	Network	Shared_Object_AMPAR_traff_model0,  CaMKII,  CaM,   PP1,  PP2B,  PP1_PSD,   PKA,  AC,  AMPAR,   AMPAR_memb
This is model 0 from Hayer and Bhalla, PLoS Comput Biol 2005. It has a bistable model of AMPAR traffick, plus a non-bistable model of CaMKII. This differs from the reference model (model 1) in that model0 lacks degradation and turno ver reactions for AMPAR.

tot_CaM_CaMKII acting as a Molecule in  AMPAR_traff_model0 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
tot_CaM_CaMKII	AMPAR_traff_ model0 Accession No. : 59	CaMKII Pathway No. : 235	0	0.09	No

tot_CaM_CaMKII acting as a Summed Molecule in  AMPAR_traff_model0 Network

	Accession Nane	Pathway Name	Target	Input
1	AMPAR_traff_ model0 Accession No. : 59	CaMKII Pathway No. : 235	tot_CaM_CaMKII	CaMKII-CaM CaMKII-thr286*-C aM
2	AMPAR_traff_ model0 Accession No. : 59	CaMKII Pathway No. : 235	act_CaMKII_cyt	tot_CaM_CaMKII tot_autonomous_ CaMKII

tot_CaM_CaMKII acting as an Enzyme in  AMPAR_traff_model0 Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	tot_CaM_CaMKII / CaM_act_305	AMPAR_traff_ model0 Accession No. : 59	CaMKII Pathway No. : 235	113.601	6	4	explicit E-S complex	Substrate CaMKII-thr286 Product CaMKII***
	Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. Jan 1 1998: Speed up 12x to match fig 5.
2	tot_CaM_CaMKII / CaM_act_286	AMPAR_traff_ model0 Accession No. : 59	CaMKII Pathway No. : 235	113.602	0.5	4	explicit E-S complex	Substrate CaMKII-CaM Product CaMKII-thr286*-C aM