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Name Notes Model

Molecule Parameter List for Anchor

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

Anchor participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	4	4

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
AMPAR_traff_ model1	60	Network	Shared_Object_AMPAR_traff_model1,  CaMKII,  CaM,   PP1,  PP2B,  PP1_PSD,   PKA,  AC,  AMPAR,   AMPAR_memb
This is the basic model of AMPAR trafficking bistability. It is based on Hayer and Bhalla, PLoS Comput. Biol. 2005. It includes the degradation and turnover of AMPARs. The CaMKII portion of the model is not bistable.

Anchor acting as a Molecule in  AMPAR_traff_model1 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
Anchor	AMPAR_traff_ model1 Accession No. : 60	AMPAR_memb Pathway No. : 253	27.3333	0.01	No

Anchor acting as a Substrate in a reaction in  AMPAR_traff_model1 Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	exo_reg**	AMPAR_traff_ model1 Accession No. : 60	AMPAR Pathway No. : 252	0.0002 (#^-1 s^-1)	0.008 (s^-1)	Not applicable**	-	Substrate A835*845*_ B835*845* Anchor Product A835*845*_ B835*845*
2	exo_reg_*	AMPAR_traff_ model1 Accession No. : 60	AMPAR Pathway No. : 252	0.0002 (#^-1 s^-1)	0.008 (s^-1)	Not applicable**	-	Substrate A845*_B831*845* Anchor Product A845*_B831*845*
3	exo_reg*_	AMPAR_traff_ model1 Accession No. : 60	AMPAR Pathway No. : 252	0.0002 (#^-1 s^-1)	0.008 (s^-1)	Not applicable**	-	Substrate A831*845*_B845* Anchor Product A831*845*_B845*
4	exo_reg__	AMPAR_traff_ model1 Accession No. : 60	AMPAR Pathway No. : 252	0.0002 (#^-1 s^-1)	0.008 (s^-1)	Not applicable**	-	Substrate A845*_B845* Anchor Product A845*_B845*
	Exo rates are scaled from earlier model versions to account for binding of anchor. We have about 200 molecules of anchor in the whole model. Here we select rates to give us a max of about 150 molecules of GluR at the synapse.

** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration

Anchor acting as a Product in a reaction in  AMPAR_traff_model1 Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	recycle**	AMPAR_traff_ model1 Accession No. : 60	AMPAR Pathway No. : 252	0.0008 (s^-1)	0 (#^-1 s^-1)	Not applicable**	-	Substrate A831*_B831* Product A831*_B831* Anchor
2	recycle_*	AMPAR_traff_ model1 Accession No. : 60	AMPAR Pathway No. : 252	0.0008 (s^-1)	0 (#^-1 s^-1)	Not applicable**	-	Substrate A_B831* Product A_B831* Anchor
3	recycle*_	AMPAR_traff_ model1 Accession No. : 60	AMPAR Pathway No. : 252	0.0008 (s^-1)	0 (#^-1 s^-1)	Not applicable**	-	Substrate A831*_B Product A831*_B Anchor
4	recycle__	AMPAR_traff_ model1 Accession No. : 60	AMPAR Pathway No. : 252	0.0008 (s^-1)	0 (#^-1 s^-1)	Not applicable**	-	Substrate A_B Product A_B Anchor

** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration