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Molecule Parameter List for CaMK-thr305

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*CaMK-thr305* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	1	0	1	1	0	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
CaMKII_model3	63	Network	Shared_Object_CaMKII_model3, CaMKII, CaM, PP1, PP2B, PP1_PSD, AC, PKA
This is the complete model of CaMKII bistability, model 3. It exhibits bistability in CaMKII activation due to autophosphorylation at the PSD and local saturation of PP1. This version of model 3 includes PKA regulatory input. This has little effect on the deterministic calculations, but the PKA pathway introduces a lot of noise which causes a difference in stochastic runs.

CaMK-thr305 acting as a Molecule in CaMKII_model3 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CaMK-thr305	CaMKII_model3 Accession No. : 63	CaMKII Pathway No. : 264	0	0.09	No
This forms due to basal autophosphorylation, but I think it has to be considered as a pathway even if some CaM is floating around. In either case it will tend to block further binding of CaM, and will not display any enzyme activity. See Hanson and Schulman JBC 267:24 pp17216-17224 1992

CaMK-thr305 acting as a Summed Molecule in CaMKII_model3 Network

Accession Name	Pathway Name	Target	Input
CaMKII_model3 Accession No. : 63	Shared_Object_ CaMKII_model3 Pathway No. : 263	tot_CaMKII_cyt	CaMKII-CaM CaMKII-thr286-C aM CaMKII-thr286 CaMKII** CaMK-thr305 CaMKII basal_CaMKII_ cyt

CaMK-thr305 acting as a Substrate for an Enzyme in CaMKII_model3 Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
PP1-active / Deph-thr305a	CaMKII_model3 Accession No. : 63	Shared_Object_ CaMKII_model3 Pathway No. : 263	5.09905	2.5	4	explicit E-S complex	Substrate CaMK-thr305 Product CaMKII

CaMK-thr305 acting as a Product of an Enzyme in CaMKII_model3 Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
PP1-active / Deph-thr286c	CaMKII_model3 Accession No. : 63	Shared_Object_ CaMKII_model3 Pathway No. : 263	5.09905	2.5	4	explicit E-S complex	Substrate CaMKII* Product** CaMK-thr305

CaMK-thr305 acting as a Product in a reaction in CaMKII_model3 Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
back_2	CaMKII_model3 Accession No. : 63	Shared_Object_ CaMKII_model3 Pathway No. : 263	0.3 (s^-1)	0 (#^-1 s^-1)	Not applicable**	-	Substrate CaMKII-thr305-PS D Product CaMK-thr305 NMDAR
Same as for back_1

** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration

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