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Accession Type:
Network
CaMKII_model3
Shared_Object_
CaMKII_model3
CaMKII
CaM
PP1
PP2B
PP1_PSD
AC
PKA

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Accession information for CaMKII_model3 (Accession Number 63)

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Accession Basic Parameters

Name CaMKII_model3
Accession Type Network
Transcriber Upinder S. Bhalla, NCBS
Developer Arnold Hayer and Upinder S. Bhalla, NCBS
Entry Date (YYYY-MM-DD) 2005-07-19
Species General Mammalian
Tissue Neuronal
Cell Compartment Synaptic Spine, Postsynaptic Density
Source Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )
Methodology Quantitative match to experiments, Qualitative
Model Implementation Exact GENESIS implementation
Model Validation Replicates original data , Approximates original data
Notes This is the complete model of CaMKII bistability, model 3. It exhibits bistability in CaMKII activation due to autophosphorylation at the PSD and local saturation of PP1. This version of model 3 includes PKA regulatory input. This has little effect on the deterministic calculations, but the PKA pathway introduces a lot of noise which causes a difference in stochastic runs.

Conversion formats

FormatFile
Native Format (GENESIS format)    acc63.g   
MATLAB format    acc63.m   
SBML format    acc63.xml   



Database compilation and code copyright (C) 2005, Upinder S. Bhalla and NCBS/TIFR
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