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Molecule Parameter List for PP1-active_PSD

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

PP1-active_PSD participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	37	0	0	1	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
AMPAR_CaMKII_ strong_coupling	64	Network	Shared_Object_AMPAR_CaMKII_strong_coupling,  CaMKII,  CaM,   PP1,  AMPAR_memb,  PP2B,   PKA,  AC,  PP1_PSD,   AMPAR
This is a model of tight coupling between the AMPAR trafficking bistability, and the CaMKII autophosphorylation bistability. In this model, the CaMKII activity is self sustaining only when AMPAR is turned on. Further, CaMKII turns on when AMPAR is turned on.

PP1-active_PSD acting as a Molecule in  AMPAR_CaMKII_strong_coupling Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
PP1-active_PSD	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	8	0.01	No
Cohen et al Meth Enz 159 390-408 is main source of info conc = 1.8 uM

PP1-active_PSD acting as an Enzyme in  AMPAR_CaMKII_strong_coupling Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PP1-active_PSD / Deph-thr286	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	2.00001	0.2	4	explicit E-S complex	Substrate CaMKII-thr286-Ca M-PSD Product CaMKII-CaM-PSD
2	PP1-active_PSD / Deph-thr286b	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	2.00001	0.2	4	explicit E-S complex	Substrate CaMKII-thr286-PS D Product CaMKII-PSD
3	PP1-active_PSD / Deph-thr305	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	2.00001	0.2	4	explicit E-S complex	Substrate CaMKII***-PSD Product CaMKII-thr286-PS D
4	PP1-active_PSD / Deph-thr286c	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	2.00001	0.2	4	explicit E-S complex	Substrate CaMKII***-PSD Product CaMKII-thr305-PS D
5	PP1-active_PSD / PP1	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	0.971451	0.17	4	explicit E-S complex	Substrate A845*_B845* Product A_B845*
6	PP1-active_PSD / PP1[1]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	0.971451	0.17	4	explicit E-S complex	Substrate A845*_B845* Product A845*_B
7	PP1-active_PSD / PP1[2]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	0.971451	0.17	4	explicit E-S complex	Substrate A845*_B Product A_B
8	PP1-active_PSD / PP1[3]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	0.971451	0.17	4	explicit E-S complex	Substrate A_B845* Product A_B
9	PP1-active_PSD / PP1[4]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	0.971451	0.17	4	explicit E-S complex	Substrate A831*845*_B845* Product A831*_B845*
10	PP1-active_PSD / PP1[5]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	0.971451	0.17	4	explicit E-S complex	Substrate A831*845*_B845* Product A831*845*_B
11	PP1-active_PSD / PP1[6]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	0.971451	0.17	4	explicit E-S complex	Substrate A831*_B845* Product A831*_B
12	PP1-active_PSD / PP1[7]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	0.971451	0.17	4	explicit E-S complex	Substrate A831*845*_B Product A831*_B
13	PP1-active_PSD / PP1[8]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	2.00005	0.35	4	explicit E-S complex	Substrate A831*845*_B845* Product A845*_B845*
14	PP1-active_PSD / PP1[9]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	2.00005	0.35	4	explicit E-S complex	Substrate A831*_B845* Product A_B845*
15	PP1-active_PSD / PP1[10]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	2.00005	0.35	4	explicit E-S complex	Substrate A831*845*_B Product A845*_B
16	PP1-active_PSD / PP1[11]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	2.00005	0.35	4	explicit E-S complex	Substrate A831*_B Product A_B
17	PP1-active_PSD / PP1[12]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	0.971451	0.17	4	explicit E-S complex	Substrate A845*_B831*845* Product A_B831*845*
18	PP1-active_PSD / PP1[13]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	0.971451	0.17	4	explicit E-S complex	Substrate A845*_B831*845* Product A845*_B831*
19	PP1-active_PSD / PP1[14]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	0.971451	0.17	4	explicit E-S complex	Substrate A_B831*845* Product A_B831*
20	PP1-active_PSD / PP1[15]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	0.971451	0.17	4	explicit E-S complex	Substrate A845*_B831* Product A_B831*
21	PP1-active_PSD / PP1[16]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	0.971451	0.17	4	explicit E-S complex	Substrate A835*845*_ B835*845* Product A831*_B831*845*
22	PP1-active_PSD / PP1[17]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	0.971451	0.17	4	explicit E-S complex	Substrate A835*845*_ B835*845* Product A831*845*_B831*
23	PP1-active_PSD / PP1[18]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	0.971451	0.17	4	explicit E-S complex	Substrate A831*_B831*845* Product A831*_B831*
24	PP1-active_PSD / PP1[19]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	0.971451	0.17	4	explicit E-S complex	Substrate A831*845*_B831* Product A831*_B831*
25	PP1-active_PSD / PP1[20]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	2.00005	0.35	4	explicit E-S complex	Substrate A_B831*845* Product A_B845*
26	PP1-active_PSD / PP1[21]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	2.00005	0.35	4	explicit E-S complex	Substrate A845*_B831*845* Product A845*_B845*
27	PP1-active_PSD / PP1[22]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	2.00005	0.35	4	explicit E-S complex	Substrate A845*_B831* Product A845*_B
28	PP1-active_PSD / PP1[23]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	2.00005	0.35	4	explicit E-S complex	Substrate A_B831* Product A_B
29	PP1-active_PSD / PP1[24]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	2.00005	0.35	4	explicit E-S complex	Substrate A835*845*_ B835*845* Product A845*_B831*845*
30	PP1-active_PSD / PP1[25]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	2.00005	0.35	4	explicit E-S complex	Substrate A831*_B831*845* Product A_B831*845*
31	PP1-active_PSD / PP1[26]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	2.00005	0.35	4	explicit E-S complex	Substrate A831*845*_B831* Product A845*_B831*
32	PP1-active_PSD / PP1[27]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	2.00005	0.35	4	explicit E-S complex	Substrate A831*_B831* Product A_B831*
33	PP1-active_PSD / PP1[28]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	2.00005	0.35	4	explicit E-S complex	Substrate A835*845*_ B835*845* Product A831*845*_B845*
34	PP1-active_PSD / PP1[29]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	2.00005	0.35	4	explicit E-S complex	Substrate A831*_B831*845* Product A831*_B845*
35	PP1-active_PSD / PP1[30]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	2.00005	0.35	4	explicit E-S complex	Substrate A831*845*_B831* Product A831*845*_B
36	PP1-active_PSD / PP1[31]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	2.00005	0.35	4	explicit E-S complex	Substrate A831*_B831* Product A831*_B
37	PP1-active_PSD / Deph-thr305a	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	2.00001	0.2	4	explicit E-S complex	Substrate CaMKII-thr305-PS D Product CaMKII-PSD

PP1-active_PSD acting as a Substrate in a reaction in  AMPAR_CaMKII_strong_coupling Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
Inact-PP1	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	499.98 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.0002(uM)	-	Substrate I1* PP1-active_PSD Product PP1-I1*
K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4

PP1-active_PSD acting as a Product in a reaction in  AMPAR_CaMKII_strong_coupling Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
dissoc-PP1-I1	AMPAR_CaMKII_ strong_coupling Accession No. : 64	PP1_PSD Pathway No. : 279	1 (s^-1)	0 (uM^-1 s^-1)	-	-	Substrate PP1-I1 Product I1 PP1-active_PSD
Let us assume that the equil in this case is very far over to the right. This is probably safe.