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Molecule Parameter List for CaMKII-CaM-PSD

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaMKII-CaM-PSD participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1202112

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • AMPAR_CaMKII_
    strong_coupling
  • 64Network
    Shared_Object_AMPAR_CaMKII_strong_coupling CaMKII CaM 
    PP1 AMPAR_memb PP2B 
    PKA AC PP1_PSD 
    AMPAR 
    This is a model of tight coupling between the AMPAR trafficking bistability, and the CaMKII autophosphorylation bistability. In this model, the CaMKII activity is self sustaining only when AMPAR is turned on. Further, CaMKII turns on when AMPAR is turned on.

    CaMKII-CaM-PSD acting as a Molecule in  
    AMPAR_CaMKII_strong_coupling Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    CaMKII-CaM-PSD
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling

    Pathway No. : 271
  • 00.01No

    CaMKII-CaM-PSD acting as a Summed Molecule in  
    AMPAR_CaMKII_strong_coupling Network
     Accession NanePathway NameTargetInput
    1
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling

    Pathway No. : 271
  • actCaMKII-PSD
  • CaMKII-thr286-Ca
    M-PSD

    CaMKII-CaM-PSD
    tot-auto-PSD
  • 2
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling

    Pathway No. : 271
  • tot-CaM-CaMKII-PSD
  • CaMKII-thr286-Ca
    M-PSD

    CaMKII-CaM-PSD

  • CaMKII-CaM-PSD acting as a Substrate for an Enzyme in  
    AMPAR_CaMKII_strong_coupling Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1tot-auto-PSD  /
    auton-286-PSD
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling

    Pathway No. : 271
  • 500.0020.54explicit E-S complexSubstrate
    CaMKII-CaM-PSD

    Product
  • CaMKII-thr286-Ca
    M-PSD

  • 2
  • tot-CaM-CaMKII-P
    SD
      /
    CaM-act-286-PSD
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling

    Pathway No. : 271
  • 319.9960.54explicit E-S complexSubstrate
    CaMKII-CaM-PSD

    Product
  • CaMKII-thr286-Ca
    M-PSD


  • CaMKII-CaM-PSD acting as a Product of an Enzyme in  
    AMPAR_CaMKII_strong_coupling Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PP1-active_PSD  /
    Deph-thr286
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling

    Pathway No. : 271
  • 2.000010.24explicit E-S complexSubstrate
  • CaMKII-thr286-Ca
    M-PSD


    Product
    CaMKII-CaM-PSD

  • CaMKII-CaM-PSD acting as a Substrate in a reaction in  
    AMPAR_CaMKII_strong_coupling Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    CaMKII-diss-CaM
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling

    Pathway No. : 271
  • 5
    (s^-1)
    0
    (uM^-1 s^-1)
    --Substrate
    CaMKII-CaM-PSD

    Product
    CaM-Ca4-PSD
    CaMKII-PSD

    CaMKII-CaM-PSD acting as a Product in a reaction in  
    AMPAR_CaMKII_strong_coupling Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1
  • CaMKII-bind-CaM-
    PSD
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling

    Pathway No. : 271
  • 49.9998
    (uM^-1 s^-1)
    0
    (s^-1)
    --Substrate
    CaM-Ca4-PSD
    CaMKII-PSD

    Product
    CaMKII-CaM-PSD
    2transloc_1
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling

    Pathway No. : 271
  • 0
    (#^-1 s^-1)
    0
    (s^-1)
    Not applicable**-Substrate
    CaMKII-CaM
    NMDAR

    Product
    CaMKII-CaM-PSD
      Rates to match curve in fig2 from Shen and Meyer, Science 284:162-166(1999), calculated for 6:1 alpha:beta CaMKII heterodimers
    ** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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