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Molecule Parameter List for CaM_Ca_n-CaNAB

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

CaM_Ca_n-CaNAB participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	38	0	0	0	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
AMPAR_CaMKII_ strong_coupling	64	Network	Shared_Object_AMPAR_CaMKII_strong_coupling,  CaMKII,  CaM,   PP1,  AMPAR_memb,  PP2B,   PKA,  AC,  PP1_PSD,   AMPAR
This is a model of tight coupling between the AMPAR trafficking bistability, and the CaMKII autophosphorylation bistability. In this model, the CaMKII activity is self sustaining only when AMPAR is turned on. Further, CaMKII turns on when AMPAR is turned on.

CaM_Ca_n-CaNAB acting as a Molecule in  AMPAR_CaMKII_strong_coupling Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CaM_Ca_n-CaNAB	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	0	0.09	No

CaM_Ca_n-CaNAB acting as an Enzyme in  AMPAR_CaMKII_strong_coupling Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	CaM_Ca_n-CaNAB / dephosph_ neurogranin	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	10.012	0.67	3.98507	explicit E-S complex	Substrate neurogranin* Product neurogranin
	From Seki et al ABB 316(2):673-679
2	CaM_Ca_n-CaNAB / dephosph_inhib1	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97079	0.34	4	explicit E-S complex	Substrate I1* Product I1
3	CaM_Ca_n-CaNAB / dephosph-PP1-I*	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97079	0.34	4	explicit E-S complex	Substrate PP1-I1* Product PP1-I1
4	CaM_Ca_n-CaNAB / dephosph_ inhib1_PSD	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97071	0.34	4	explicit E-S complex	Substrate I1* Product I1
5	CaM_Ca_n-CaNAB / dephosph-PP1-I*_ PSD	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97071	0.34	4	explicit E-S complex	Substrate PP1-I1* Product PP1-I1
6	CaM_Ca_n-CaNAB / PP2B[17]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A845*_B Product A_B
7	CaM_Ca_n-CaNAB / PP2B[18]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A831*845*_B Product A831*_B
8	CaM_Ca_n-CaNAB / PP2B[19]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A845*_B831* Product A_B831*
9	CaM_Ca_n-CaNAB / PP2B[20]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A831*845*_B831* Product A831*_B831*
10	CaM_Ca_n-CaNAB / PP2B[21]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A_B845* Product A_B
11	CaM_Ca_n-CaNAB / PP2B[22]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A831*_B845* Product A831*_B
12	CaM_Ca_n-CaNAB / PP2B[23]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A_B831*845* Product A_B831*
13	CaM_Ca_n-CaNAB / PP2B[24]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A831*_B831*845* Product A831*_B831*
14	CaM_Ca_n-CaNAB / PP2B[25]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A845*_B845* Product A_B845*
15	CaM_Ca_n-CaNAB / PP2B[26]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A831*845*_B845* Product A831*_B845*
16	CaM_Ca_n-CaNAB / PP2B[27]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A845*_B831*845* Product A_B831*845*
17	CaM_Ca_n-CaNAB / PP2B[28]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A835*845*_ B835*845* Product A831*_B831*845*
18	CaM_Ca_n-CaNAB / PP2B[29]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A845*_B845* Product A845*_B
19	CaM_Ca_n-CaNAB / PP2B[30]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A831*845*_B845* Product A831*845*_B
20	CaM_Ca_n-CaNAB / PP2B[31]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A845*_B831*845* Product A845*_B831*
21	CaM_Ca_n-CaNAB / PP2B[32]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A835*845*_ B835*845* Product A831*845*_B831*
22	CaM_Ca_n-CaNAB / PP2B	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A845*_B845* Product A_B845*
23	CaM_Ca_n-CaNAB / PP2B[1]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A845*_B845* Product A845*_B
24	CaM_Ca_n-CaNAB / PP2B[2]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A_B845* Product A_B
25	CaM_Ca_n-CaNAB / PP2B[3]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A845*_B Product A_B
26	CaM_Ca_n-CaNAB / PP2B[4]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A831*845*_B845* Product A831*_B845*
27	CaM_Ca_n-CaNAB / PP2B[5]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A831*845*_B845* Product A831*845*_B
28	CaM_Ca_n-CaNAB / PP2B[6]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A831*_B845* Product A831*_B
29	CaM_Ca_n-CaNAB / PP2B[7]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A831*845*_B Product A831*_B
30	CaM_Ca_n-CaNAB / PP2B[8]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A845*_B831*845* Product A_B831*845*
31	CaM_Ca_n-CaNAB / PP2B[9]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A845*_B831*845* Product A845*_B831*
32	CaM_Ca_n-CaNAB / PP2B[10]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A_B831*845* Product A_B831*
33	CaM_Ca_n-CaNAB / PP2B[11]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A845*_B831* Product A_B831*
34	CaM_Ca_n-CaNAB / PP2B[12]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A835*845*_ B835*845* Product A831*_B831*845*
35	CaM_Ca_n-CaNAB / PP2B[13]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A835*845*_ B835*845* Product A831*845*_B831*
36	CaM_Ca_n-CaNAB / PP2B[14]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A831*845*_B831* Product A831*_B831*
37	CaM_Ca_n-CaNAB / PP2B[15]	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	4.97061	2	4	explicit E-S complex	Substrate A831*_B831*845* Product A831*_B831*
38	CaM_Ca_n-CaNAB / dephosph_ neurogranin_PSD	AMPAR_CaMKII_ strong_coupling Accession No. : 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. : 271	10.012	0.67	3.98507	explicit E-S complex	Substrate neurogranin*_ PSD Product neurogranin_PSD
	From Seki et al ABB 316(2):673-679

CaM_Ca_n-CaNAB acting as a Product in a reaction in  AMPAR_CaMKII_strong_coupling Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
CaMCa4-bind-CaNA B	AMPAR_CaMKII_ strong_coupling Accession No. : 64	PP2B Pathway No. : 276	599.994 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.0017(uM)	-	Substrate CaM-Ca4 CaNAB-Ca4 Product CaM_Ca_n-CaNAB