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Molecule Parameter List for neurogranin*_PSD

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
neurogranin*_PSD participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1001210

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • AMPAR_CaMKII_
    strong_coupling
  • 64Network
    Shared_Object_AMPAR_CaMKII_strong_coupling CaMKII CaM 
    PP1 AMPAR_memb PP2B 
    PKA AC PP1_PSD 
    AMPAR 
    This is a model of tight coupling between the AMPAR trafficking bistability, and the CaMKII autophosphorylation bistability. In this model, the CaMKII activity is self sustaining only when AMPAR is turned on. Further, CaMKII turns on when AMPAR is turned on.

    neurogranin*_PSD acting as a Molecule in  
    AMPAR_CaMKII_strong_coupling Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    neurogranin*_PSD
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • CaM
    Pathway No. : 273
    00.01No
    The phosph form does not bind CaM (Huang et al ABB 305:2 570-580 1993)

    neurogranin*_PSD acting as a Substrate for an Enzyme in  
    AMPAR_CaMKII_strong_coupling Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    CaM_Ca_n-CaNAB  /
  • dephosph_
    neurogranin_PSD
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling

    Pathway No. : 271
  • 10.0120.673.98507explicit E-S complexSubstrate
  • neurogranin*_
    PSD


    Product
    neurogranin_PSD
  • From Seki et al ABB 316(2):673-679

    neurogranin*_PSD acting as a Product of an Enzyme in  
    AMPAR_CaMKII_strong_coupling Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1PKC-active  /

  • PKC-phosph-neuro
    granin_
    PSD
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling

    Pathway No. : 271
  • 28.62730.584.03448explicit E-S complexSubstrate
    neurogranin_PSD

    Product
  • neurogranin*_
    PSD

  •     Rates from Huang et al ABB 305:2 570-580 1993
    2PKC-active  /

  • PKC-phosph-ng-Ca
    M_
    PSD
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling

    Pathway No. : 271
  • 28.59560.354explicit E-S complexSubstrate

  • neurogranin-CaM_
    PSD


    Product
    CaM-PSD
  • neurogranin*_
    PSD

  •     Rates are 60% those of PKC-phosph-neurogranin. See Huang et al ABB 305:2 570-580 1993

    neurogranin*_PSD acting as a Substrate in a reaction in  
    AMPAR_CaMKII_strong_coupling Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents

  • dephosph-neurogr
    anin_
    PSD
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • CaM
    Pathway No. : 273
    0.005
    (s^-1)
    0
    (s^-1)
    --Substrate
  • neurogranin*_
    PSD


    Product
    neurogranin_PSD
  • This is put in to keep the basal levels of neurogranin* experimentally reasonable. From various papers, specially Ramakers et al JBC 270:23 1995 13892-13898, it looks like the basal level of phosph is between 20 and 40%. I est around 25 % The kf of 0.005 gives around this level at basal PKC activity levels of 0.1 uM active PKC.



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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