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Molecule Parameter List for IFN | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| IFN participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 0 | 0 | 0 | 0 | 2 | 0 |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Jak-Stat_
Pathway | 66 | Pathway |
Jak-Stat_Pathway | This model was taken from the Yamada S et al. FEBS Letters 2003 Jan 16;534(1-3):190-6
This model shows the control mechanism of Jak-Stat pathway, here SOCS1 (Suppressor of cytokine signaling-I) was identified as the negative regulator of Jak and STAT signal transduction pathway.
Note: There are a few ambiguities in the paper like initial concentration of IFN and some reactions were missing in the paper that were employed for obtaining the results. The graphs are almost similar to the graphs as shown in the paper but still some ambiguities regarding the concentration are there. Thanks to Dr Satoshi Yamada for clarifying some of those ambiguities and providing the values used in the simulations. |
IFN acting as a Molecule in Jak-Stat_Pathway Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | IFN | Jak-Stat_
Pathway
Accession No. : 66 | Jak-Stat_
Pathway
Pathway No. : 293 | 0.01 | 0.0016667 | Yes | | IFN gamma liganding to the IFN gamma receptor that has JAK bound to its intracellular domain. IFN = 10nM = 0.01uM Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
IFN acting as a Substrate in a reaction in Jak-Stat_Pathway Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | IFN_binding | Jak-Stat_
Pathway
Accession No. : 66 | Jak-Stat_
Pathway
Pathway No. : 293 | 20
(uM^-1 s^-1) | 0.02
(s^-1) | Kd(bf) = 0.001(uM) | - | Substrate
IFN
RJ
Product
IFNRJ
| | | Binding of JAK to the intracellular domain of the IFN gamma receptor Kf = 20*10e+06 /M/sec = 20/uM/sec Kb = 0.02 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 | | 2 | IFN-R_bind | Jak-Stat_
Pathway
Accession No. : 66 | Jak-Stat_
Pathway
Pathway No. : 293 | 20
(uM^-1 s^-1) | 0.02
(s^-1) | Kd(bf) = 0.001(uM) | - | Substrate
IFN
R
Product
IFNR
| | | Binding reaction of IFN + R. kf = 20/sec/uM kb = 0.02/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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