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Molecule Parameter List for Transcription_comp2

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
Transcription_comp2 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1010000

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Jak-Stat_
    Pathway
    		• 66Pathway
    Jak-Stat_Pathway 
    This model was taken from the Yamada S et al. FEBS Letters 2003 Jan 16;534(1-3):190-6
    This model shows the control mechanism of Jak-Stat pathway, here SOCS1 (Suppressor of cytokine signaling-I) was identified as the negative regulator of Jak and STAT signal transduction pathway.
    Note: There are a few ambiguities in the paper like initial concentration of IFN and some reactions were missing in the paper that were employed for obtaining the results. The graphs are almost similar to the graphs as shown in the paper but still some ambiguities regarding the concentration are there. Thanks to Dr Satoshi Yamada for clarifying some of those ambiguities and providing the values used in the simulations.

    Transcription_comp2 acting as a Molecule in      Jak-Stat_Pathway Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    Transcription_comp2
  • Jak-Stat_
    Pathway
    Accession No. : 66
  • Jak-Stat_
    Pathway
    Pathway No. : 293
    		• 0.0010.0016667Yes
    DNA to which STAT1*D and other transcription factors bound. Appendix, Sattoshi Yamada et al 2003 FEBS Letters 534;190-196.

    Transcription_comp2 acting as an Enzyme in      Jak-Stat_Pathway Network
    Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
  • Transcription_
    comp2     /
    DNA
  • Jak-Stat_
    Pathway
    Accession No. : 66
  • Jak-Stat_
    Pathway
    Pathway No. : 293
    		• 0.40.014Classical Michaelis-Menten
    V = Etot.S.Kcat/Km+S    		Substrate
  • dup_
    STAT1n*-STAT1n*

    Product
    mRNAVn
    • Translation of mRNAVn Km = 400nM = 0.4uM kcat = 0.01/sec Appendix, Satoshi Yamada 2003 FEBS Letters 534:190-196.