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Molecule Parameter List for dup_STAT1n*-STAT1n*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
dup_STAT1n*-STAT1n* participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1101000

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
SOCS1_knockout67Pathway
SOCS1_knockout 
This model was taken from the Yamada S et al. FEBS Letters 2003 Jan 16;534(1-3):190-6
This model shows the control mechanism of Jak-Stat pathway, here SOCS1 (Suppressor of cytokine signaling-I) was identified as the negative regulator of Jak and STAT signal transduction pathway. This is the knockout version of Jak-Stat pathway in this model the SOCS1 has been knocked out i.e it formation is not shown.
The graphs are almost similar to the graphs as shown in the paper but STAT1n graph has some ambiguities. Thanks to Dr Satoshi Yamada for clarifying some of those ambiguities and providing the values used in the simulations.

dup_STAT1n*-STAT1n* acting as a Molecule in  SOCS1_knockout Network
NameAccession NamePathway NameInitial Conc.
(uM)		Volume
(fL)		Buffered
dup_STAT1n*-STAT1n*SOCS1_knockout
Accession No. : 67		SOCS1_knockout
Pathway No. : 294		00.0016667No
Duplicate of the STAT1c dimer Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196

dup_STAT1n*-STAT1n* acting as a Summed Molecule in  SOCS1_knockout Network
Accession NamePathway NameTargetInput
SOCS1_knockout
Accession No. : 67		SOCS1_knockout
Pathway No. : 294		dup_STAT1n*-STAT1n*STAT1n*-STAT1n*
Duplicate of the STAT1c dimer Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196

dup_STAT1n*-STAT1n* acting as a Substrate for an Enzyme in  SOCS1_knockout Network
Enzyme Molecule /
Enzyme Activity		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
  • Transcription_
    comp2      /
    DNA
    		• SOCS1_knockout
    Accession No. : 67    		SOCS1_knockout
    Pathway No. : 294    		0.40.014Classical Michaelis-Menten
    V = Etot.S.Kcat/Km+S    		Substrate
  • dup_
    STAT1n*-STAT1n*

    Product
    mRNAVn
    • DNA Km = 0.4uM kcat = 0.01/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534;190-196.


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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