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Molecule Parameter List for dup_STAT1n*-STAT1n* | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| dup_STAT1n*-STAT1n* participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 1 | 0 | 1 | 0 | 0 | 0 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
| SOCS1_knockout | 67 | Pathway | SOCS1_knockout |
| This model was taken from the Yamada S et al. FEBS Letters 2003 Jan 16;534(1-3):190-6 This model shows the control mechanism of Jak-Stat pathway, here SOCS1 (Suppressor of cytokine signaling-I) was identified as the negative regulator of Jak and STAT signal transduction pathway. This is the knockout version of Jak-Stat pathway in this model the SOCS1 has been knocked out i.e it formation is not shown. The graphs are almost similar to the graphs as shown in the paper but STAT1n graph has some ambiguities. Thanks to Dr Satoshi Yamada for clarifying some of those ambiguities and providing the values used in the simulations. | |||
dup_STAT1n*-STAT1n* acting as a Molecule in SOCS1_knockout Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| dup_STAT1n*-STAT1n* | SOCS1_knockout Accession No. : 67 | SOCS1_knockout Pathway No. : 294 | 0 | 0.0016667 | No | |
| Duplicate of the STAT1c dimer Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 | ||||||
dup_STAT1n*-STAT1n* acting as a Summed Molecule in SOCS1_knockout Network
| Accession Name | Pathway Name | Target | Input |
| SOCS1_knockout Accession No. : 67 | SOCS1_knockout Pathway No. : 294 | dup_STAT1n*-STAT1n* | STAT1n*-STAT1n* |
| Duplicate of the STAT1c dimer Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 | |||
dup_STAT1n*-STAT1n* acting as a Substrate for an Enzyme in SOCS1_knockout Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents |
comp2 / DNA | SOCS1_knockout Accession No. : 67 | SOCS1_knockout Pathway No. : 294 | 0.4 | 0.01 | 4 | Classical Michaelis-Menten V = Etot.S.Kcat/Km+S | Substrate STAT1n*-STAT1n* Product mRNAVn |
| DNA Km = 0.4uM kcat = 0.01/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534;190-196. | |||||||