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Molecule Parameter List for Transcription_comp2

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
Transcription_comp2 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1010000

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
SOCS1_knockout67Pathway
SOCS1_knockout 
This model was taken from the Yamada S et al. FEBS Letters 2003 Jan 16;534(1-3):190-6
This model shows the control mechanism of Jak-Stat pathway, here SOCS1 (Suppressor of cytokine signaling-I) was identified as the negative regulator of Jak and STAT signal transduction pathway. This is the knockout version of Jak-Stat pathway in this model the SOCS1 has been knocked out i.e it formation is not shown.
The graphs are almost similar to the graphs as shown in the paper but STAT1n graph has some ambiguities. Thanks to Dr Satoshi Yamada for clarifying some of those ambiguities and providing the values used in the simulations.

Transcription_comp2 acting as a Molecule in  
SOCS1_knockout Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
Transcription_comp2SOCS1_knockout
Accession No. : 67
SOCS1_knockout
Pathway No. : 294
0.0010.0016667Yes
Transcription complex for mRNAVn Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196.

Transcription_comp2 acting as an Enzyme in  
SOCS1_knockout Network
Enzyme Molecule /
Enzyme Activity
Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
  • Transcription_
    comp2
     /
    DNA
  • SOCS1_knockout
    Accession No. : 67
    SOCS1_knockout
    Pathway No. : 294
    0.40.014Classical Michaelis-Menten
    V = Etot.S.Kcat/Km+S
    Substrate
  • dup_
    STAT1n*-STAT1n*


    Product
    mRNAVn
  • DNA Km = 0.4uM kcat = 0.01/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534;190-196.



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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