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Molecule Parameter List for GDP.Ran-nuclear | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| GDP.Ran-nuclear participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 0 | 0 | 0 | 0 | 1 | 2 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
| RanGTPase | 70 | Network | Shared_Object_RanGTPase, Nucleus, Cytoplasm |
| This model represents a concentration gradient of RanGTP across the nuclear envelope. This gradient is generated by distribution of regulators of RanGTPase. We have taken a log linear plot of graphs generated by GENESIS and compared with the experimental graphs. | |||
GDP.Ran-nuclear acting as a Molecule in RanGTPase Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| GDP.Ran-nuclear | RanGTPase Accession No. : 70 | Nucleus Pathway No. : 305 | 0 | 12000 | No | |
| nuclear-GDP.Ran Nuclear fraction of GDP bound Ran Approximately 71% of RanGDP in the nucleus is bound Nuclear volume = 1.2 pL = 1.2e-15 m^3 Gorlich D et al (2003) EMBO J 22(5):1088-1100 | ||||||
GDP.Ran-nuclear acting as a Substrate in a reaction in RanGTPase Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
| RCC1_binding | RanGTPase Accession No. : 70 | Nucleus Pathway No. : 305 | 74.0006 (uM^-1 s^-1) | 55 (s^-1) | Kd(bf) = 0.7432(uM) | - | Substrate GDP.Ran-nuclear RCC1 Product RCC1-GDP.Ran |
| Binding of GDP-Ran complex with RCC1 Kf = 7.4e+07 /M/sec = 7.4e+01 /uM/sec Kb = 55 /sec Christian Klebe et al (1995) Biochemistry 34:12543-12552. Supplementary Table A Gorlich D et al (2003) EMBO J 22(5):1088-1100 | |||||||
GDP.Ran-nuclear acting as a Product in a reaction in RanGTPase Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | |
| 1 | dissociation[1] | RanGTPase Accession No. : 70 | Nucleus Pathway No. : 305 | 0.48 (s^-1) | 0 (#^-1 s^-1) | Not applicable** | - | Substrate .Ran Product GDP.Ran-nuclear NTF2 |
| Approximation of reaction rates to match the kinetics described by Gorlich D et al (2003) EMBO J 22(5):1088-1100 | ||||||||
| 2 | dissociation | RanGTPase Accession No. : 70 | Cytoplasm Pathway No. : 306 | 0.48 (s^-1) | 0 (#^-1 s^-1) | Not applicable** | - | Substrate NTF2-GDP.Ran Product GDP.Ran-nuclear NTF2 |
| Approximation of rates to match the kinetics described by Gorlich D et al (2003) EMBO J 22(5):1088-1100 | ||||||||