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Molecule Parameter List for Imidazole | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| Imidazole participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | NMArginine | 74 | Pathway |
NMArginine | This model is taken from the Abu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51. This model shows kinetic binding of NMArginine to neuronal nitric oxide synthase.
Model shows the substrate (NM-Arginine) binding to nNOS in a two-step reversible fashion. First there is rapid binding equilibrium between Im-nNOS and NM-Arginine to form an intermediate that contains bound imidazole and NM-arginine. This is followed by a slower conformational change in the Im-enzyme-substrate complex that is associated with release of bound imidazole and generation of a modified enzyme-substrate complex which is detected due to spectral change. Rates approximated based on data in Table 2. The rates for first reaction are not exact since only Kd known and appropriate graphs do not exist for matching the kinetic profile.
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Imidazole acting as a Molecule in NMArginine Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | Imidazole | NMArginine
Accession No. : 74 | NMArginine
Pathway No. : 310 | 0 | 0.0016667 | No | | Imidazole released from the neuronal Nitric Oxide Synthasecomplexed to NM-Arginine. Abu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51. |
Imidazole acting as a Product in a reaction in NMArginine Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | Imidazole_
release | NMArginine
Accession No. : 74 | NMArginine
Pathway No. : 310 | 27
(s^-1) | 0.2
(uM^-1 s^-1) | Kd(cb) = 0.0074(uM) | - | Substrate
Im-nNOS-NM-Argin
ine
Product
Imidazole
nNOS-NM-Arginine
| | Release of Imidazole from complex ofNM-Arginine and Imidazole bound rat brainneuronal Nitric Oxide Synthase. Abu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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