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Molecule Parameter List for PLA2-Ca*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PLA2-Ca* participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1010021

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Ajay_Bhalla_
    2004_Feedback_
    Tuning
    		• 78Network
    Shared_Object_Ajay_Bhalla_2004_Feedback_Tuning,  PKC,  PLA2,  
    PLCbeta,  Gq,  MAPK,  
    Ras,  EGFR,  Sos,  
    PLC_g,  CaMKII,  CaM,  
    PP1,  PP2B,  PKA,  
    AC 
    This model is taken from Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. This is the feedback model from Figure 8a.

    PLA2-Ca* acting as a Molecule in      Ajay_Bhalla_2004_Feedback_Tuning Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    PLA2-Ca*
  • Ajay_Bhalla_
    2004_Feedback_
    Tuning
    Accession No. : 78
    		• PLA2
    Pathway No. : 349    		01.5No

    PLA2-Ca* acting as an Enzyme in      Ajay_Bhalla_2004_Feedback_Tuning Network
    Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PLA2-Ca* /
    kenz
  • Ajay_Bhalla_
    2004_Feedback_
    Tuning
    Accession No. : 78
    		• PLA2
    Pathway No. : 349    		205.44explicit E-S complexSubstrate
    APC

    Product
    AA
    10 x raise oct22 12 x oct 24, set k2 = 4 * k3

    PLA2-Ca* acting as a Substrate in a reaction in      Ajay_Bhalla_2004_Feedback_Tuning Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1
  • PIP2-Ca-PLA2-act
  • Ajay_Bhalla_
    2004_Feedback_
    Tuning
    Accession No. : 78
    		• PLA2
    Pathway No. : 349    		0.012
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 8.3335(uM)-Substrate
    PLA2-Ca*
    temp-PIP2

    Product
    PIP2-Ca-PLA2*
    2DAG-Ca-PLA2-act
  • Ajay_Bhalla_
    2004_Feedback_
    Tuning
    Accession No. : 78
    		• PLA2
    Pathway No. : 349    		0.003
    (uM^-1 s^-1)    		4
    (s^-1)    		Kd(bf) = 1333.3467(uM)-Substrate
    DAG
    PLA2-Ca*

    Product
    DAG-Ca-PLA2*
      27 June 1996 Scaled kf down by 0.015 from 3.33e-7 to 5e-9 to fit with revised DAG estimates and use of mole-fraction to calculate eff on PLA2.

    PLA2-Ca* acting as a Product in a reaction in      Ajay_Bhalla_2004_Feedback_Tuning Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    PLA2-Ca-act
  • Ajay_Bhalla_
    2004_Feedback_
    Tuning
    Accession No. : 78
    		• PLA2
    Pathway No. : 349    		1
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.1(uM)-Substrate
    Ca
    PLA2-cytosolic

    Product
    PLA2-Ca*
    Leslie and Channon BBA 1045 (1990) 261-270 fig6 pp267.


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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