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Molecule Parameter List for PKC-DAG

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

PKC-DAG participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	25	0	0	0	0	24	49

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Ajay_bhalla_ 2007_ReacDiff1_ 1e-12	81	Network	Shared_Object_Ajay_bhalla_2007_ReacDiff1_1e-12,   PKC,  MAPK,  Ras,  CaM,  PKM,  chain,  kinetics,  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[1],   PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[2],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[3],   PKC,  MAPK,  MAPK,  Ras,  CaM,  PKM,  kinetics[4],  PKC,  MAPK,  Ras,  CaM,  PKM,   kinetics[5],  PKC,  MAPK,  Ras,  kinetics[6],  CaM,  PKM,  PKC,  MAPK,  Ras,   CaM,  PKM,  kinetics[7],  PKC,  Ras,  CaM,  PKM,  kinetics[8],  PKC,  MAPK,   Ras,  CaM,  PKM,  kinetics[9],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[10],   PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[11],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[12],   PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[13],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[14],   PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[15],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[16],   PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[17],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[18],   PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[19],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[20],   PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[21],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[22],   PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[23],  PKC,  MAPK,  Ras,  CaM,  PKM
This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_PKM model. The original single-compartment model is repeated 25 times. In addition, a subset (27 out of 42) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. For D = 1e-12 m^2/sec (i.e., 1 micron^2/sec ) the kf and kb of this reaction for these 10 micron compartments are both 0.01/sec. For D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) the kf and kb are 0.001/sec. The stimulus file pkm_mapk22_diff_1e-12_Fig4A which was used for the model to replicate Figure 4A from the paper. This stimulus file pkm_mapk22_diff_1e-12_Fig4G which was used for the model to replicate Figure 4G from the paper

PKC-DAG acting as a Molecule in  Ajay_bhalla_2007_ReacDiff1_1e-12 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
PKC-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 376	0	1.5	No
CoInit was .0624
PKC-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 383	0	1.5	No
CoInit was .0624
PKC-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 389	0	1.5	No
CoInit was .0624
PKC-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 395	0	1.5	No
CoInit was .0624
PKC-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 401	0	1.5	No
CoInit was .0624
PKC-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 408	0	1.5	No
CoInit was .0624
PKC-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 414	0	1.5	No
CoInit was .0624
PKC-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 420	0	1.5	No
CoInit was .0624
PKC-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 426	0	1.5	No
CoInit was .0624
PKC-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 431	0	1.5	No
CoInit was .0624
PKC-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 437	0	1.5	No
CoInit was .0624
PKC-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 443	0	1.5	No
CoInit was .0624
PKC-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 449	0	1.5	No
CoInit was .0624
PKC-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 455	0	1.5	No
CoInit was .0624
PKC-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 461	0	1.5	No
CoInit was .0624
PKC-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 467	0	1.5	No
CoInit was .0624
PKC-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 473	0	1.5	No
CoInit was .0624
PKC-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 479	0	1.5	No
CoInit was .0624
PKC-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 485	0	1.5	No
CoInit was .0624
PKC-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 491	0	1.5	No
CoInit was .0624
PKC-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 497	0	1.5	No
CoInit was .0624
PKC-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 503	0	1.5	No
CoInit was .0624
PKC-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 509	0	1.5	No
CoInit was .0624
PKC-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 515	0	1.5	No
CoInit was .0624
PKC-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 521	0	1.5	No
CoInit was .0624

PKC-DAG acting as a Substrate in a reaction in  Ajay_bhalla_2007_ReacDiff1_1e-12 Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
2	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
3	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
4	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
5	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
6	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
7	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
8	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
9	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
10	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
11	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
12	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
13	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
14	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
15	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
16	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
17	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
18	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
19	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
20	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
21	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
22	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
23	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
24	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG

PKC-DAG acting as a Product in a reaction in  Ajay_bhalla_2007_ReacDiff1_1e-12 Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 376	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
2	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
3	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 383	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
4	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
5	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 389	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
6	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
7	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 395	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
8	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
9	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 401	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
10	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
11	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 408	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
12	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
13	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 414	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
14	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
15	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 420	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
16	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
17	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 473	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
18	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 426	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
19	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
20	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 431	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
21	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
22	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 437	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
23	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
24	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 443	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
25	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
26	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 449	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
27	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
28	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 455	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
29	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
30	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 461	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
31	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
32	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 467	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
33	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
34	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
35	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 479	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
36	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
37	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 485	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
38	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
39	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 491	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
40	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
41	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 497	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
42	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
43	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 503	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
44	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
45	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 509	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
46	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
47	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 515	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
48	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-DAG Product PKC-DAG
49	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 521	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9