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Molecule Parameter List for DAG

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

DAG participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	25	0	0	0	0	50	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Ajay_bhalla_ 2007_ReacDiff1_ 1e-12	81	Network	Shared_Object_Ajay_bhalla_2007_ReacDiff1_1e-12,   PKC,  MAPK,  Ras,  CaM,  PKM,  chain,  kinetics,  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[1],   PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[2],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[3],   PKC,  MAPK,  MAPK,  Ras,  CaM,  PKM,  kinetics[4],  PKC,  MAPK,  Ras,  CaM,  PKM,   kinetics[5],  PKC,  MAPK,  Ras,  kinetics[6],  CaM,  PKM,  PKC,  MAPK,  Ras,   CaM,  PKM,  kinetics[7],  PKC,  Ras,  CaM,  PKM,  kinetics[8],  PKC,  MAPK,   Ras,  CaM,  PKM,  kinetics[9],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[10],   PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[11],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[12],   PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[13],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[14],   PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[15],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[16],   PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[17],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[18],   PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[19],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[20],   PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[21],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[22],   PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[23],  PKC,  MAPK,  Ras,  CaM,  PKM
This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_PKM model. The original single-compartment model is repeated 25 times. In addition, a subset (27 out of 42) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. For D = 1e-12 m^2/sec (i.e., 1 micron^2/sec ) the kf and kb of this reaction for these 10 micron compartments are both 0.01/sec. For D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) the kf and kb are 0.001/sec. The stimulus file pkm_mapk22_diff_1e-12_Fig4A which was used for the model to replicate Figure 4A from the paper. This stimulus file pkm_mapk22_diff_1e-12_Fig4G which was used for the model to replicate Figure 4G from the paper

DAG acting as a Molecule in  Ajay_bhalla_2007_ReacDiff1_1e-12 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	12.2	1.5	Yes
DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	kinetics Pathway No. : 382	12.2	1.5	Yes
DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	kinetics[1] Pathway No. : 388	12.2	1.5	Yes
DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	kinetics[2] Pathway No. : 394	12.2	1.5	Yes
DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	kinetics[3] Pathway No. : 400	12.2	1.5	Yes
DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	kinetics[4] Pathway No. : 407	12.2	1.5	Yes
DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	kinetics[5] Pathway No. : 413	12.2	1.5	Yes
DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	kinetics[6] Pathway No. : 417	12.2	1.5	Yes
DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	kinetics[7] Pathway No. : 425	12.2	1.5	Yes
DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	kinetics[8] Pathway No. : 430	12.2	1.5	Yes
DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	kinetics[9] Pathway No. : 436	12.2	1.5	Yes
DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	kinetics[10] Pathway No. : 442	12.2	1.5	Yes
DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	kinetics[11] Pathway No. : 448	12.2	1.5	Yes
DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	kinetics[12] Pathway No. : 454	12.2	1.5	Yes
DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	kinetics[13] Pathway No. : 460	12.2	1.5	Yes
DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	kinetics[14] Pathway No. : 466	12.2	1.5	Yes
DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	kinetics[15] Pathway No. : 472	12.2	1.5	Yes
DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	kinetics[16] Pathway No. : 478	12.2	1.5	Yes
DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	kinetics[17] Pathway No. : 484	12.2	1.5	Yes
DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	kinetics[18] Pathway No. : 490	12.2	1.5	Yes
DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	kinetics[19] Pathway No. : 496	12.2	1.5	Yes
DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	kinetics[20] Pathway No. : 502	12.2	1.5	Yes
DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	kinetics[21] Pathway No. : 508	12.2	1.5	Yes
DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	kinetics[22] Pathway No. : 514	12.2	1.5	Yes
DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	kinetics[23] Pathway No. : 520	12.2	1.5	Yes

DAG acting as a Substrate in a reaction in  Ajay_bhalla_2007_ReacDiff1_1e-12 Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	PKC-act-by-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 376	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
2	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 376	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
3	PKC-act-by-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 383	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
4	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 383	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
5	PKC-act-by-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 401	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
6	PKC-act-by-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 389	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
7	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 389	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
8	PKC-act-by-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 395	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
9	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 395	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
10	PKC-act-by-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 426	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
11	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 401	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
12	PKC-act-by-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 408	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
13	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 408	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
14	PKC-act-by-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 414	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
15	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 414	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
16	PKC-act-by-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 420	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
17	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 420	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
18	PKC-act-by-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 473	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
19	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 473	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
20	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 426	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
21	PKC-act-by-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 431	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
22	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 431	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
23	PKC-act-by-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 437	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
24	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 437	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
25	PKC-act-by-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 443	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
26	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 443	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
27	PKC-act-by-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 449	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
28	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 449	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
29	PKC-act-by-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 455	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
30	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 455	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
31	PKC-act-by-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 461	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
32	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 461	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
33	PKC-act-by-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 467	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
34	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 467	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
35	PKC-act-by-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 479	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
36	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 479	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
37	PKC-act-by-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 485	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
38	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 485	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
39	PKC-act-by-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 491	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
40	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 491	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
41	PKC-act-by-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 497	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
42	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 497	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
43	PKC-act-by-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 503	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
44	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 503	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
45	PKC-act-by-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 509	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
46	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 509	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
47	PKC-act-by-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 515	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
48	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 515	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
49	PKC-act-by-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 521	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.4148(uM)	-	Substrate DAG PKC-Ca Product PKC-Ca-DAG
	Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
50	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 521	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9