NCBS Home page
Accession List
Pathway List
Search
Authorized Users
Help
News archives

Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.
Search in: Search for Match By

Molecule Parameter List for DAG

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
DAG participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences250000500

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    		• 81NetworkShared_Object_Ajay_bhalla_2007_ReacDiff1_1e-12,  
    PKC,  MAPK,  Ras,  CaM,  PKM,  chain,  kinetics,  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[1],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[2],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[3],  
    PKC,  MAPK,  MAPK,  Ras,  CaM,  PKM,  kinetics[4],  PKC,  MAPK,  Ras,  CaM,  PKM,  
    kinetics[5],  PKC,  MAPK,  Ras,  kinetics[6],  CaM,  PKM,  PKC,  MAPK,  Ras,  
    CaM,  PKM,  kinetics[7],  PKC,  Ras,  CaM,  PKM,  kinetics[8],  PKC,  MAPK,  
    Ras,  CaM,  PKM,  kinetics[9],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[10],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[11],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[12],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[13],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[14],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[15],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[16],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[17],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[18],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[19],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[20],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[21],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[22],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[23],  PKC,  MAPK,  Ras,  CaM,  PKM 
    This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_PKM model. The original single-compartment model is repeated 25 times. In addition, a subset (27 out of 42) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. For D = 1e-12 m^2/sec (i.e., 1 micron^2/sec ) the kf and kb of this reaction for these 10 micron compartments are both 0.01/sec. For D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) the kf and kb are 0.001/sec.
    The stimulus file pkm_mapk22_diff_1e-12_Fig4A which was used for the model to replicate Figure 4A from the paper.
    This stimulus file pkm_mapk22_diff_1e-12_Fig4G which was used for the model to replicate Figure 4G from the paper

    DAG acting as a Molecule in      Ajay_bhalla_2007_ReacDiff1_1e-12 Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
  • Shared_Object_
    Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Pathway No. : 375
    		• 12.21.5Yes
    DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics
    Pathway No. : 382    		12.21.5Yes
    DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[1]
    Pathway No. : 388    		12.21.5Yes
    DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[2]
    Pathway No. : 394    		12.21.5Yes
    DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[3]
    Pathway No. : 400    		12.21.5Yes
    DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[4]
    Pathway No. : 407    		12.21.5Yes
    DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[5]
    Pathway No. : 413    		12.21.5Yes
    DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[6]
    Pathway No. : 417    		12.21.5Yes
    DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[7]
    Pathway No. : 425    		12.21.5Yes
    DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[8]
    Pathway No. : 430    		12.21.5Yes
    DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[9]
    Pathway No. : 436    		12.21.5Yes
    DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[10]
    Pathway No. : 442    		12.21.5Yes
    DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[11]
    Pathway No. : 448    		12.21.5Yes
    DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[12]
    Pathway No. : 454    		12.21.5Yes
    DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[13]
    Pathway No. : 460    		12.21.5Yes
    DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[14]
    Pathway No. : 466    		12.21.5Yes
    DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[15]
    Pathway No. : 472    		12.21.5Yes
    DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[16]
    Pathway No. : 478    		12.21.5Yes
    DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[17]
    Pathway No. : 484    		12.21.5Yes
    DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[18]
    Pathway No. : 490    		12.21.5Yes
    DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[19]
    Pathway No. : 496    		12.21.5Yes
    DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[20]
    Pathway No. : 502    		12.21.5Yes
    DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[21]
    Pathway No. : 508    		12.21.5Yes
    DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[22]
    Pathway No. : 514    		12.21.5Yes
    DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[23]
    Pathway No. : 520    		12.21.5Yes

    DAG acting as a Substrate in a reaction in      Ajay_bhalla_2007_ReacDiff1_1e-12 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1PKC-act-by-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 376    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    2PKC-n-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 376    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    3PKC-act-by-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 383    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    4PKC-n-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 383    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    5PKC-act-by-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 401    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    6PKC-act-by-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 389    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    7PKC-n-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 389    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    8PKC-act-by-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 395    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    9PKC-n-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 395    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    10PKC-act-by-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 426    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    11PKC-n-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 401    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    12PKC-act-by-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 408    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    13PKC-n-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 408    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    14PKC-act-by-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 414    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    15PKC-n-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 414    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    16PKC-act-by-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 420    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    17PKC-n-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 420    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    18PKC-act-by-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 473    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    19PKC-n-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 473    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    20PKC-n-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 426    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    21PKC-act-by-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 431    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    22PKC-n-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 431    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    23PKC-act-by-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 437    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    24PKC-n-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 437    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    25PKC-act-by-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 443    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    26PKC-n-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 443    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    27PKC-act-by-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 449    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    28PKC-n-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 449    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    29PKC-act-by-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 455    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    30PKC-n-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 455    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    31PKC-act-by-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 461    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    32PKC-n-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 461    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    33PKC-act-by-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 467    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    34PKC-n-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 467    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    35PKC-act-by-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 479    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    36PKC-n-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 479    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    37PKC-act-by-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 485    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    38PKC-n-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 485    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    39PKC-act-by-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 491    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    40PKC-n-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 491    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    41PKC-act-by-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 497    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    42PKC-n-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 497    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    43PKC-act-by-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 503    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    44PKC-n-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 503    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    45PKC-act-by-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 509    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    46PKC-n-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 509    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    47PKC-act-by-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 515    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    48PKC-n-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 515    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    49PKC-act-by-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 521    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    50PKC-n-DAG
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• PKC
    Pathway No. : 521    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.