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Molecule Parameter List for DAG

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
DAG participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences400000800

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Ajay_Bhalla_
    2007_ReacDiff2
    		• 83NetworkShared_Object_Ajay_Bhalla_2007_ReacDiff,  PKC,  MAPK,  
    Ras,  CaM,  PKM,  chain,  kinetics,  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[1],  
    PKC,  MAPK,  Ras,  kinetics[3],  CaM,  PKM,  kinetics[2],  PKC,  MAPK,  Ras,  
    CaM,  PKM,  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[4],  PKC,  MAPK,  Ras,  CaM,  
    PKM,  kinetics[5],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[6],  PKC,  MAPK,  
    Ras,  CaM,  PKM,  kinetics[7],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[8],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[9],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[10],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[11],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[12],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[13],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[14],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[15],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[16],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[17],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[18],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[19],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[20],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[21],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[22],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[23],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[24],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[25],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[26],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[27],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[28],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[29],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[30],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[31],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[32],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[33],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[34],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[35],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[36],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[37],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[38],  
    PKC,  MAPK,  Ras,  CaM,  PKM 
    This is a 40-compartment reaction-diffusion-transport version of the Ajay_Bhalla_2007_PKM model. The original single-compartment model is repeated 40 times. In addition, a subset (27 out of 42) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. For D = 1e-12 m^2/sec (i.e., 1 micron^2/sec ) the kf and kb of this reaction for these 10 micron compartments are both 0.01/sec In addition, we have a forward (dendrite to soma) transport term of 1 microns/sec. This converts to a rate of 0.1/sec, but applies only to the kf. So the total kf of the diffusion 'reaction' is 0.11 for D = 1 micron^2/sec, and kb is 0.01. If D=0.1 micron^2/sec then kf = 0.101 and kb = 0.001. In addition this model has all molecules buffered in the first and last compartments. This boundary conditions says that the molecules are not drained out of the first compartment, nor do they all pile up in the last one.
    The stimulus file pkm_mapk22_transp_endbuf_D1e-13_Fig4CD which was used for the model to replicate Figure 4C and 4D from the paper.

    DAG acting as a Molecule in      Ajay_Bhalla_2007_ReacDiff2 Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff
    Pathway No. : 677
    		• 12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics
    Pathway No. : 684    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[1]
    Pathway No. : 690    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[2]
    Pathway No. : 697    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[3]
    Pathway No. : 694    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[4]
    Pathway No. : 708    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[5]
    Pathway No. : 714    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[6]
    Pathway No. : 720    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[7]
    Pathway No. : 726    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[8]
    Pathway No. : 732    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[9]
    Pathway No. : 738    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[10]
    Pathway No. : 744    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[11]
    Pathway No. : 750    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[12]
    Pathway No. : 756    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[13]
    Pathway No. : 762    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[14]
    Pathway No. : 768    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[31]
    Pathway No. : 870    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[15]
    Pathway No. : 774    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[16]
    Pathway No. : 780    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[17]
    Pathway No. : 786    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[18]
    Pathway No. : 792    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[19]
    Pathway No. : 798    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[20]
    Pathway No. : 804    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[21]
    Pathway No. : 810    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[22]
    Pathway No. : 816    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[23]
    Pathway No. : 822    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[24]
    Pathway No. : 828    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[25]
    Pathway No. : 834    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[26]
    Pathway No. : 840    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[27]
    Pathway No. : 846    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[28]
    Pathway No. : 852    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[29]
    Pathway No. : 858    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[30]
    Pathway No. : 864    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[32]
    Pathway No. : 876    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[33]
    Pathway No. : 882    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[34]
    Pathway No. : 888    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[35]
    Pathway No. : 894    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[36]
    Pathway No. : 900    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[37]
    Pathway No. : 906    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• kinetics[38]
    Pathway No. : 912    		12.21.5Yes

    DAG acting as a Substrate in a reaction in      Ajay_Bhalla_2007_ReacDiff2 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 678    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    2PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 678    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    3PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 685    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    4PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 685    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    5PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 703    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    6PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 691    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    7PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 691    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    8PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 698    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    9PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 698    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    10PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 727    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    11PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 703    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    12PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 709    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    13PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 709    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    14PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 715    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    15PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 715    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    16PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 721    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    17PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 721    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    18PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 775    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    19PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 775    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    20PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 727    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    21PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 733    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    22PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 733    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    23PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 739    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    24PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 739    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    25PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 745    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    26PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 745    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    27PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 751    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    28PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 751    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    29PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 757    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    30PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 757    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    31PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 763    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    32PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 763    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    33PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 769    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    34PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 769    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    35PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 871    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    36PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 871    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    37PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 781    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    38PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 781    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    39PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 787    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    40PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 787    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    41PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 793    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    42PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 793    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    43PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 799    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    44PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 799    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    45PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 805    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    46PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 805    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    47PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 811    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    48PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 811    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    49PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 817    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    50PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 817    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    51PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 823    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    52PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 823    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    53PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 829    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    54PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 829    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    55PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 835    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    56PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 835    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    57PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 841    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    58PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 841    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    59PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 847    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    60PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 847    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    61PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 853    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    62PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 853    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    63PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 859    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    64PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 859    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    65PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 865    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    66PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 865    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    67PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 877    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    68PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 877    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    69PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 883    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    70PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 883    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    71PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 889    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    72PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 889    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    73PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 895    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    74PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 895    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    75PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 901    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    76PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 901    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    77PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 907    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    78PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 907    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    79PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 913    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    80PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff2
    Accession No. : 83
    		• PKC
    Pathway No. : 913    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9


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