Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.

Search in:

ALL Accession Pathway Molecule Enzyme Reaction Connected to

Search for

Match

Anything Exact Word Starting With

By

Name Notes Model

Molecule Parameter List for IE

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

IE participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	1	1	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Mammalian_cell_ cycle	85	Network	Growth,  CELLDIV,  Rb_grp,   IE_GRP,  CycB_Grp,  Cdc20_Grp,   Cdh1_grp,  E2F,  CycA_Grp,   CycE_grp,  Early_Response_Genes,  Delayed_Response_Genes,   CycD_Grp
This is a fairly complete mass-action reimplementation of the Novak and Tyson mammalian cell cycle model. It is inexact on two counts. First, it replaces many rather abstracted equations with mass action and Michaelis-Menten forms of enzymes. Second, it does not handle the halving of cellular volume at the division point. Within these limitations, the model does most of what the original paper shows including oscillation of the relevant molecules.

IE acting as a Molecule in  Mammalian_cell_cycle Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
IE	Mammalian_cell_ cycle Accession No. : 85	IE_GRP Pathway No. : 1072	1	200	No
According to the paper: IE is an intermediary enzyme that creates a time delay between CycB accumulation and Cdc20 activation. No initial value for this is given. I assume it is 1.

IE acting as a Substrate for an Enzyme in  Mammalian_cell_cycle Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
CycB  / k31	Mammalian_cell_ cycle Accession No. : 85	CELLDIV Pathway No. : 1070	0.00999989	0.7	4	explicit E-S complex	Substrate IE Product IEP
Represented as k31.[IE].[CycB]/(J31 + [IE]) k31 = 0.7 J31 = 0.01

IE acting as a Product of an Enzyme in  Mammalian_cell_cycle Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
PPX  / k32	Mammalian_cell_ cycle Accession No. : 85	IE_GRP Pathway No. : 1072	0.01	1.8	4	explicit E-S complex	Substrate IEP Product IE
Represented as k32.[PPx].[IEP] / (J32 + [IEP]) k32 = 1.8 J32 = 0.01