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Molecule Parameter List for IE | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Mammalian_cell_
cycle | 85 | Network |
Growth, CELLDIV, Rb_grp,
IE_GRP, CycB_Grp, Cdc20_Grp,
Cdh1_grp, E2F, CycA_Grp,
CycE_grp, Early_Response_Genes, Delayed_Response_Genes,
CycD_Grp | | This is a fairly complete mass-action reimplementation of the Novak and Tyson mammalian cell cycle model. It is inexact on two counts. First, it replaces many rather abstracted equations with mass action and Michaelis-Menten forms of enzymes. Second, it does not handle the halving of cellular volume at the division point. Within these limitations, the model does most of what the original paper shows including oscillation of the relevant molecules. |
IE acting as a Molecule in Mammalian_cell_cycle Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | IE | Mammalian_cell_
cycle
Accession No. : 85 | IE_GRP
Pathway No. : 1072 | 1 | 200 | No | | According to the paper: IE is an intermediary enzyme that creates a time delay between CycB accumulation and Cdc20 activation. No initial value for this is given. I assume it is 1. |
IE acting as a Substrate for an Enzyme in Mammalian_cell_cycle Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | CycB /
k31 | Mammalian_cell_
cycle
Accession No. : 85 | CELLDIV
Pathway No. : 1070 | 0.00999989 | 0.7 | 4 | explicit E-S complex | Substrate
IE
Product
IEP
| | Represented as k31.[IE].[CycB]/(J31 + [IE]) k31 = 0.7 J31 = 0.01 |
IE acting as a Product of an Enzyme in Mammalian_cell_cycle Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | PPX /
k32 | Mammalian_cell_
cycle
Accession No. : 85 | IE_GRP
Pathway No. : 1072 | 0.01 | 1.8 | 4 | explicit E-S complex | Substrate
IEP
Product
IE
| | Represented as k32.[PPx].[IEP] / (J32 + [IEP]) k32 = 1.8 J32 = 0.01 |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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