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Molecule Parameter List for Cdh1 | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Mammalian_cell_
cycle | 85 | Network |
Growth, CELLDIV, Rb_grp,
IE_GRP, CycB_Grp, Cdc20_Grp,
Cdh1_grp, E2F, CycA_Grp,
CycE_grp, Early_Response_Genes, Delayed_Response_Genes,
CycD_Grp | | This is a fairly complete mass-action reimplementation of the Novak and Tyson mammalian cell cycle model. It is inexact on two counts. First, it replaces many rather abstracted equations with mass action and Michaelis-Menten forms of enzymes. Second, it does not handle the halving of cellular volume at the division point. Within these limitations, the model does most of what the original paper shows including oscillation of the relevant molecules. |
Cdh1 acting as a Molecule in Mammalian_cell_cycle Network
Cdh1 acting as an Enzyme in Mammalian_cell_cycle Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | Cdh1 /
Cdh1_k2
| Mammalian_cell_
cycle
Accession No. : 85 | Cdh1_grp
Pathway No. : 1075 | 100 | 2000 | 4 | explicit E-S complex | Substrate
CycB
Product
degraded
| | k2 = 20 Let Km = 100, so it is >> substrate. Then kcat = Km * k2 = 2000 |
Cdh1 acting as a Substrate for an Enzyme in Mammalian_cell_cycle Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | CycA /
Cdh1_CycA | Mammalian_cell_
cycle
Accession No. : 85 | CELLDIV
Pathway No. : 1070 | 0.01 | 12 | 4 | explicit E-S complex | Substrate
Cdh1
Product
Cdh1_i
| | | J4 = Km = 0.01 k4 = 40. GammaA = 0.3 kcat = k4 * GammaA = 12 | | 2 | CycB /
Cdh1_CycB | Mammalian_cell_
cycle
Accession No. : 85 | CELLDIV
Pathway No. : 1070 | 0.0099998 | 40 | 4 | explicit E-S complex | Substrate
Cdh1
Product
Cdh1_i
| | | Eqn 12. J4 = Km = 0.01 k4 = 40 GammaB = 1 kcat = k4 * GammaB = 40 |
Cdh1 acting as a Product of an Enzyme in Mammalian_cell_cycle Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | Cdc20 /
Cdh1_Cdc20 | Mammalian_cell_
cycle
Accession No. : 85 | CELLDIV
Pathway No. : 1070 | 0.0100001 | 140 | 4 | explicit E-S complex | Substrate
Cdh1_i
Product
Cdh1
| | | k3 = 140 Km = j3 = 0.01 | | 2 | k3_prime /
k3_prime | Mammalian_cell_
cycle
Accession No. : 85 | Cdh1_grp
Pathway No. : 1075 | 0.01 | 7.5 | 4 | explicit E-S complex | Substrate
Cdh1_i
Product
Cdh1
| | | k3_prime = 7.5 J3 = Km = 0.01 Rate = [k3_prime] * [Cdh1_i]/(J3 + [Cdh1_i]) |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
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