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Molecule Parameter List for Cdh1

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

Cdh1 participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	1	2	2	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Mammalian_cell_ cycle	85	Network	Growth,  CELLDIV,  Rb_grp,   IE_GRP,  CycB_Grp,  Cdc20_Grp,   Cdh1_grp,  E2F,  CycA_Grp,   CycE_grp,  Early_Response_Genes,  Delayed_Response_Genes,   CycD_Grp
This is a fairly complete mass-action reimplementation of the Novak and Tyson mammalian cell cycle model. It is inexact on two counts. First, it replaces many rather abstracted equations with mass action and Michaelis-Menten forms of enzymes. Second, it does not handle the halving of cellular volume at the division point. Within these limitations, the model does most of what the original paper shows including oscillation of the relevant molecules.

Cdh1 acting as a Molecule in  Mammalian_cell_cycle Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
Cdh1	Mammalian_cell_ cycle Accession No. : 85	Cdh1_grp Pathway No. : 1075	0	200	No

Cdh1 acting as an Enzyme in  Mammalian_cell_cycle Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
Cdh1 / Cdh1_k2	Mammalian_cell_ cycle Accession No. : 85	Cdh1_grp Pathway No. : 1075	100	2000	4	explicit E-S complex	Substrate CycB Product degraded
k2 = 20 Let Km = 100, so it is >> substrate. Then kcat = Km * k2 = 2000

Cdh1 acting as a Substrate for an Enzyme in  Mammalian_cell_cycle Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	CycA  / Cdh1_CycA	Mammalian_cell_ cycle Accession No. : 85	CELLDIV Pathway No. : 1070	0.01	12	4	explicit E-S complex	Substrate Cdh1 Product Cdh1_i
	J4 = Km = 0.01 k4 = 40. GammaA = 0.3 kcat = k4 * GammaA = 12
2	CycB  / Cdh1_CycB	Mammalian_cell_ cycle Accession No. : 85	CELLDIV Pathway No. : 1070	0.0099998	40	4	explicit E-S complex	Substrate Cdh1 Product Cdh1_i
	Eqn 12. J4 = Km = 0.01 k4 = 40 GammaB = 1 kcat = k4 * GammaB = 40

Cdh1 acting as a Product of an Enzyme in  Mammalian_cell_cycle Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	Cdc20  / Cdh1_Cdc20	Mammalian_cell_ cycle Accession No. : 85	CELLDIV Pathway No. : 1070	0.0100001	140	4	explicit E-S complex	Substrate Cdh1_i Product Cdh1
	k3 = 140 Km = j3 = 0.01
2	k3_prime  / k3_prime	Mammalian_cell_ cycle Accession No. : 85	Cdh1_grp Pathway No. : 1075	0.01	7.5	4	explicit E-S complex	Substrate Cdh1_i Product Cdh1
	k3_prime = 7.5 J3 = Km = 0.01 Rate = [k3_prime] * [Cdh1_i]/(J3 + [Cdh1_i])