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Molecule Parameter List for CycB_dimer | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Mammalian_cell_
cycle | 85 | Network |
Growth, CELLDIV, Rb_grp,
IE_GRP, CycB_Grp, Cdc20_Grp,
Cdh1_grp, E2F, CycA_Grp,
CycE_grp, Early_Response_Genes, Delayed_Response_Genes,
CycD_Grp | | This is a fairly complete mass-action reimplementation of the Novak and Tyson mammalian cell cycle model. It is inexact on two counts. First, it replaces many rather abstracted equations with mass action and Michaelis-Menten forms of enzymes. Second, it does not handle the halving of cellular volume at the division point. Within these limitations, the model does most of what the original paper shows including oscillation of the relevant molecules. |
CycB_dimer acting as a Molecule in Mammalian_cell_cycle Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | CycB_dimer | Mammalian_cell_
cycle
Accession No. : 85 | CycB_Grp
Pathway No. : 1073 | 0 | 200 | No |
CycB_dimer acting as a Substrate for an Enzyme in Mammalian_cell_cycle Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | CycB_synth /
k1 | Mammalian_cell_
cycle
Accession No. : 85 | CycB_Grp
Pathway No. : 1073 | 0.01 | 0.6 | 4 | explicit E-S complex | Substrate
CycB_dimer
Product
CycB
| | k1 = 0.6. J1 = 0.1 rate = k1([CycB]/J1)^2 / (1 + ([cycB]/J1)^2 ) 2nd order term comes from dimerization, assume rate = k1 * dimer. Doing our usual assumption of AA = Km = 1, we get kcat = 2 * k1 = 1.2 7 April. Revisit this. Multiply expression above and below by J1^2. Then we have standard MM form, with k1 = kcat, and J1^2 = Km. 19 Apr 2005. Altered layout so that dimer form is in substrate, which it should have been all along. |
CycB_dimer acting as a Product in a reaction in Mammalian_cell_cycle Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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