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Molecule Parameter List for ERG_synth

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
ERG_synth participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1010010

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Mammalian_cell_
    cycle
  • 85Network
    Growth CELLDIV Rb_grp 
    IE_GRP CycB_Grp Cdc20_Grp 
    Cdh1_grp E2F CycA_Grp 
    CycE_grp Early_Response_Genes Delayed_Response_Genes 
    CycD_Grp 
    This is a fairly complete mass-action reimplementation of the Novak and Tyson mammalian cell cycle model. It is inexact on two counts. First, it replaces many rather abstracted equations with mass action and Michaelis-Menten forms of enzymes. Second, it does not handle the halving of cellular volume at the division point. Within these limitations, the model does most of what the original paper shows including oscillation of the relevant molecules.

    ERG_synth acting as a Molecule in  
    Mammalian_cell_cycle Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    ERG_synth
  • Mammalian_cell_
    cycle

    Accession No. : 85
  • Early_Response_
    Genes

    Pathway No. : 1079
  • 1200No
    Enzyme that synthesiszes ERG. Enters into equations only implicitly. Initial conc set to 1.

    ERG_synth acting as an Enzyme in  
    Mammalian_cell_cycle Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    ERG_synth /
    ERG_synth
  • Mammalian_cell_
    cycle

    Accession No. : 85
  • Early_Response_
    Genes

    Pathway No. : 1079
  • 1.000020.54explicit E-S complexSubstrate
    AminoAcids

    Product
    ERG
    kcat = 2 * k15 = 0.5 Km = 1 [AA] = 1

    ERG_synth acting as a Substrate in a reaction in  
    Mammalian_cell_cycle Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • DRG2_bind_ERG_
    synth
  • Mammalian_cell_
    cycle

    Accession No. : 85
  • Early_Response_
    Genes

    Pathway No. : 1079
  • 99.9996
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.01(uM)-Substrate
    DRG_2B
    ERG_synth

    Product
    inhib_ERG_synth
    Kd = J15^2 = (0.1)^2 = 0.01



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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