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Molecule Parameter List for k14_enz

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

k14_enz participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	1	0	0	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Mammalian_cell_ cycle	85	Network	Growth,  CELLDIV,  Rb_grp,   IE_GRP,  CycB_Grp,  Cdc20_Grp,   Cdh1_grp,  E2F,  CycA_Grp,   CycE_grp,  Early_Response_Genes,  Delayed_Response_Genes,   CycD_Grp
This is a fairly complete mass-action reimplementation of the Novak and Tyson mammalian cell cycle model. It is inexact on two counts. First, it replaces many rather abstracted equations with mass action and Michaelis-Menten forms of enzymes. Second, it does not handle the halving of cellular volume at the division point. Within these limitations, the model does most of what the original paper shows including oscillation of the relevant molecules.

k14_enz acting as a Molecule in  Mammalian_cell_cycle Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
k14_enz	Mammalian_cell_ cycle Accession No. : 85	Cdc20_Grp Pathway No. : 1074	1	200	Yes

k14_enz acting as an Enzyme in  Mammalian_cell_cycle Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
k14_enz / k14	Mammalian_cell_ cycle Accession No. : 85	Cdc20_Grp Pathway No. : 1074	0.00500008	2.5	4	explicit E-S complex	Substrate Cdc20 Product Cdc20notA
Represented as k14.[Cdc20] / (J4 + [Cdc20]) But I suspect it should be J14. k14 = 2.5 J14 = 0.005 If we set enz = 1, Km = J14, kcat = k14, this equation applies.