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Molecule Parameter List for Mass_dup | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Mammalian_cell_
cycle | 85 | Network |
Growth, CELLDIV, Rb_grp,
IE_GRP, CycB_Grp, Cdc20_Grp,
Cdh1_grp, E2F, CycA_Grp,
CycE_grp, Early_Response_Genes, Delayed_Response_Genes,
CycD_Grp | | This is a fairly complete mass-action reimplementation of the Novak and Tyson mammalian cell cycle model. It is inexact on two counts. First, it replaces many rather abstracted equations with mass action and Michaelis-Menten forms of enzymes. Second, it does not handle the halving of cellular volume at the division point. Within these limitations, the model does most of what the original paper shows including oscillation of the relevant molecules. |
Mass_dup acting as a Molecule in Mammalian_cell_cycle Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | Mass_dup | Mammalian_cell_
cycle
Accession No. : 85 | CELLDIV
Pathway No. : 1070 | 0 | 200 | No |
Mass_dup acting as a Summed Molecule in Mammalian_cell_cycle Network
Mass_dup acting as a Substrate for an Enzyme in Mammalian_cell_cycle Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | E2FA /
k29 | Mammalian_cell_
cycle
Accession No. : 85 | CELLDIV
Pathway No. : 1070 | 1000.02 | 50 | 4 | explicit E-S complex | Substrate
Mass_dup
Product
CycA
| | Represented as eps*k29*[E2FA]*[mass], where k29 is 0.05 Split into two steps, this one deals with the E2FA term. rate = Mass_dup * E2FA * kcat / (Km + Mass_dup) Note that Mass_dup will not change. Let Km >> Mass_dup and kcat = k29 * Km. then rate ~ Mass_dup * E2FA * k29 * Km / Km |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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