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Molecule Parameter List for Shc*_Grb2-Gab1_PI3K_clx | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| Shc*_Grb2-Gab1_PI3K_clx participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 0 | 1 | 0 | 0 | 0 | 1 |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | BDNF_Receptor | 86 | Network |
Shared_Object_BDNF_Receptor, TrKB_mod, PI3K_mod | | BDNF recetor signaling is one of the sub-model in BDNF signaling cascade. BDNF activates TrKB, leading to the stimulation of PI3K and formation of PIP3. |
Shc*_Grb2-Gab1_PI3K_clx acting as a Molecule in BDNF_Receptor Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | Shc*_Grb2-Gab1_PI3K_clx | BDNF_Receptor
Accession No. : 86 | TrKB_mod
Pathway No. : 1083 | 0 | 999.97 | No |
Shc*_Grb2-Gab1_PI3K_clx acting as an Enzyme in BDNF_Receptor Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | Shc*_Grb2-Gab1_
PI3K_clx /
Phospho
| BDNF_Receptor
Accession No. : 86 | TrKB_mod
Pathway No. : 1083 | 4.00001 | 4 | 4 | explicit E-S complex | Substrate
PIP2
Product
PIP3
|
Shc*_Grb2-Gab1_PI3K_clx acting as a Product in a reaction in BDNF_Receptor Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | PI3K_act | BDNF_Receptor
Accession No. : 86 | PI3K_mod
Pathway No. : 1084 | 5.0002
(uM^-1 s^-1) | 0.08
(s^-1) | Kd(bf) = 0.016(uM) | - | Substrate
PI3K
Shc*_Grb2-Gab1_
clx
Product
Shc*_Grb2-Gab1_
PI3K_clx
|
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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