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Molecule Parameter List for PKC-basal*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PKC-basal* participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1100001

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • MAPK_MKP1_
    oscillation
    		• 9Network
    Shared_Object_MAPK_MKP1_oscillation,  PKC,  MAPK,  
    PLA2,  Ras 
    This model relates to figure 5 in Bhalla US, Iyengar R. Chaos (2001) 11(1):221-226. It includes the model used for figures 2-4 and also has MKP-1 induction by MAPK activity in the synapse. PP2A is set to 0.16 uM and MKP synthesis is varied from 5x to 40 x basal to get a range of interesting behaviours.

    PKC-basal* acting as a Molecule in      MAPK_MKP1_oscillation Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    PKC-basal*
  • MAPK_MKP1_
    oscillation
    Accession No. : 9
    		• PKC
    Pathway No. : 60    		0.021000No

    PKC-basal* acting as a Summed Molecule in      MAPK_MKP1_oscillation Network
    Accession NamePathway NameTargetInput
  • MAPK_MKP1_
    oscillation
    Accession No. : 9
  • Shared_Object_
    MAPK_MKP1_
    oscillation
    Pathway No. : 59
    		• PKC-activePKC-DAG-AA*
    PKC-Ca-memb*
    PKC-Ca-AA*
    PKC-DAG-memb*
    PKC-basal*
    PKC-AA*
    Conc of PKC in brain is about 1 uM (?)

    PKC-basal* acting as a Product in a reaction in      MAPK_MKP1_oscillation Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    PKC-basal-act
  • MAPK_MKP1_
    oscillation
    Accession No. : 9
    		• PKC
    Pathway No. : 60    		1
    (s^-1)    		50
    (s^-1)    		Keq = 50(uM)0.02secSubstrate
    PKC-cytosolic

    Product
    PKC-basal*
    Initial basal levels were set by kf = 1, kb = 20. In model, though, the basal levels of PKC activity are higher.


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.