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Molecule List for pathway PKC (Pathway Number 71) in Accession Synaptic_Network (Accession Number 16) |
Default ordering is done according to Pathway Number. Table headers can be used for changing the default ordering.  arrow indicates that ordering is done according to ascending or descending order.The entries are grouped according to Pathway Number and are alternately color coded using  and  color. |
| Name | Accession Type | Initial Conc. (uM) | Volume (fL) | Buffered | Sum Total Of | |||
| 1 | PKC-Ca | Network | 0 | 1000 | No | - | ||
| This intermediate is strongly indicated by the synergistic activation of PKC by combinations of DAG and Ca, as well as AA and Ca. PKC by definition also has a direct Ca-activation, to which this also contributes. | ||||||||
| 2 | PKC-DAG-AA* | Network | 0 | 1000 | No | - | ||
| Membrane translocated form of PKC-DAG-AA complex. | ||||||||
| 3 | PKC-Ca-AA* | Network | 0 | 1000 | No | - | ||
| Membrane bound and active complex of PKC, Ca and AA. | ||||||||
| 4 | PKC-Ca-memb* | Network | 0 | 1000 | No | - | ||
| This is the direct Ca-stimulated activity of PKC. | ||||||||
| 5 | PKC-DAG-memb* | Network | 0 | 1000 | No | - | ||
| Active, membrane attached form of Ca.DAG.PKC complex. | ||||||||
| 6 | PKC-basal* | Network | 0.02 | 1000 | No | - | ||
| This is the basal PKC activity which contributes about 2% to the maximum. | ||||||||
| 7 | PKC-AA* | Network | 0 | 1000 | No | - | ||
| This is the membrane-bound and active form of the PKC-AA complex. | ||||||||
| 8 | PKC-Ca-DAG | Network | 0 | 1000 | No | - | ||
| This is the active PKC form involving Ca and DAG. It has to translocate to the membrane. | ||||||||
| 9 | PKC-DAG | Network | 0 | 1000 | No | - | ||
| This is a DAG-bound intermediate used in synergistic activation of PKC by DAG and AA. | ||||||||
| 10 | PKC-DAG-AA | Network | 0 | 1000 | No | - | ||
| Complex of PKC, DAG and AA giving rise to synergistic activation of PKC by DAG and AA at resting Ca. | ||||||||
| 11 | PKC-cytosolic | Network | 1 | 1000 | No | - | ||
| Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells Kikkawa et al 1982 JBC 257(22):13341 have PKC levels in brain at about 1 uM. The cytosolic form is the inactive PKC. This is really a composite of three isoforms: alpha, beta and gamma which have slightly different properties and respond to different combinations of Ca, AA and DAG. | ||||||||