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Molecule List for pathway AC (Pathway Number 197) in Accession PKA_2003 (Accession Number 47) | Default ordering is done according to Pathway Number. Table headers can be used for changing the default ordering.
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The entries are grouped according to Pathway Number and are alternately color coded using  and  color. |
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Name | Accession
Type | Initial
Conc.
(uM) | Volume
(fL) | Buffered | Sum Total Of | | 1 | ATP | Network | 5000 | 0 | Yes | - | | | ATP is present in all cells between 2 and 10 mM. See Lehninger. It is assumed buffered since the metabolic activity will take care of its levels. | | 2 | AMP | Network | 1000 | 0 | Yes | - | | | Assumed buffered to 1 mM. Value is irrelevant to simulation. | | 3 | cAMP-PDE | Network | 0.5 | 0 | No | - | | | The levels of the PDE are not known at this time. However, enough kinetic info and info about steady-state levels of cAMP etc are around to make it possible to estimate this at about 0.5 uM. | | 4 | AC | Network | 0.015 | 0 | No | - | | | AC is present at rather low levels. Here we use 0.015 uM which is meant to lump various isoforms. None of the isoforms nor the other specific regulators are included here. Jacobowitz, PhD thesis. | | 5 | cAMP-PDE* | Network | 0 | 0 | No | - | | | This form has about 2X activity as plain PDE. See Sette et al (1994 Jul 15) J Biol Chem. 269(28):18271-4 | | 6 | Gs.AC | Network | 0 | 0 | No | - | | | This is the active form of the cyclase. |
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