| |
Name | Accession
Type | Initial
Conc.
(uM) | Volume
(fL) | Buffered | Sum Total Of |
| 1 | PDE1 | Network | 2.5926 | 0 | No | - |
| | CaM-Dependent PDE. Amount calculated from total rate in brain vs. specific rate. |
| 2 | cAMP_in_dend | Network | 0 | 0 | No | - |
| | Assume a 5 uM long segment of 1 uM^2 Xsection dendrite. |
| 3 | cAMP-PDE* | Network | 0 | 0 | No | - |
| | This form has about 2X activity as plain PDE. See Sette et al JBC 269:28 18271-18274 1994. |
| 4 | cAMP-PDE | Network | 0.5556 | 0 | No | - |
| | The levels of the PDE are not known at this time. However, enough kinetic info and info about steady-state levels of cAMP etc are around to make it possible to estimate this. 18 Feb 2005: After some playing with initial conc, it is now back at 0.5 uM. |
| 5 | CaM.PDE1 | Network | 0 | 0 | No | - |
| | Activity up 6x following Ca-CaM binding. |
| 6 | ATP | Network | 2000 | 0 | Yes | - |
| | ATP is present in all cells between 2 and 10 mM. See Lehninger |
| 7 | AMP | Network | 0 | 0 | No | - |
| 8 | AC2* | Network | 0 | 0 | No | - |
| | This version is activated by Gs and by a betagamma and phosphorylation. |
| 9 | AC2 | Network | 0.0741 | 0 | No | - |
| | Starting at 0.015 uM. 17 Feb 2005: Raised slightly so as to have integer number of molecules. 18 Feb 2005: Doubled, to compensate for reduced ATP. |
| 10 | AC1-CaM | Network | 0 | 0 | No | - |
| | This version of cyclase is Calmodulin activated. Gs stims it but betagamma inhibits. |
| 11 | AC1 | Network | 0.0741 | 0 | No | - |
| | Starting conc at 20 nM. Reduced conc to 10 nM, 14.8. Arnold 17 Feb 2005. Raised conc back to about 18 nM, for an nInit of precisely 1. 18 Feb. Doubled conc, to compensate for reduced ATP. 18 Feb. Doublec conc again, halved Vmax. |
and 
color.