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Reaction List for pathway PLA2 (Pathway Number 365) in Accession Ajay_Bhalla_2007_Bistable (Accession Number 79) |
Entries are grouped according to Pathway Number and they are alternately color coded using  and  color.
Further ordering can be done to the table header.   indicates that ordering is done according to ascending or descending order.Keq is calculated only for first order reactions. Kd is calculated only for second order reactions. [nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules] |
| Reaction Name | Pathway Name / Pathway No. | Kf | Kb | Kd | tau | Reagents | |
| 1 | PLA2-Ca-act | PLA2 Pathway No. 365 | 1 (uM^-1 s^-1) | 0.1 (s^-1) | Kd(bf) = 0.1(uM) | - | Substrate: PLA2-cytosolic Ca Products: PLA2-Ca* | Leslie and Channon BBA 1045 (1990) 261-270 fig6 pp267. |
| 2 | PIP2-PLA2-act | PLA2 Pathway No. 365 | 0.0012 (uM^-1 s^-1) | 0.5 (s^-1) | Kd(bf) = 416.6632(uM) | - | Substrate: temp-PIP2 PLA2-cytosolic Products: PIP2-PLA2* |
| 3 | | PLA2 Pathway No. 365 | 0.012 (uM^-1 s^-1) | 0.1 (s^-1) | Kd(bf) = 8.3333(uM) | - | Substrate: temp-PIP2 PLA2-Ca* Products: PIP2-Ca-PLA2* |
| 4 | DAG-Ca-PLA2-act | PLA2 Pathway No. 365 | 0.003 (uM^-1 s^-1) | 4 (s^-1) | Kd(bf) = 1333.3422(uM) | - | Substrate: DAG PLA2-Ca* Products: DAG-Ca-PLA2* | 27 June 1996 Scaled kf down by 0.015 from 3.33e-7 to 5e-9 to fit with revised DAG estimates and use of mole-fraction to calculate eff on PLA2. |
| 5 | Degrade-AA | PLA2 Pathway No. 365 | 0.4 (s^-1) | 0 (s^-1) | - | - | Substrate: AA Products: APC | I need to check if the AA degradation pathway really leads back to APC. Anyway, it is a convenient buffered pool to dump it back into. For the purposes of the full model we use a rate of degradation of 0.2/sec Raised decay to 0.4 : see PLA35.g notes for Feb17 |
| 6 | PLA2*-Ca-act | PLA2 Pathway No. 365 | 6 (uM^-1 s^-1) | 0.1 (s^-1) | Kd(bf) = 0.0167(uM) | - | Substrate: PLA2* Ca Products: PLA2*-Ca | To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien.... |
| 7 | PLA2* | PLA2 Pathway No. 365 | 0.17 (s^-1) | 0 (s^-1) | - | - | Substrate: PLA2* Products: PLA2-cytosolic |