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Reaction List for pathway Ras (Pathway Number 63) in Accession MAPK_MKP1_oscillation (Accession Number 9) | Entries are grouped according to Pathway Number and they are alternately color coded using  and  color.
Further ordering can be done to the table header.   indicates that ordering is done according to ascending or descending order.
Keq is calculated only for first order reactions.
Kd is calculated only for second order reactions. [nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules] |
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Reaction
Name | Pathway Name /
Pathway No. | Kf | Kb | Kd | tau | Reagents | | 1 | dephosph-GEF | Ras
Pathway No. 63 | 1
(s^-1) | 0
(s^-1) | - | - | Substrate:
GEF*
Products:
inact-GEF
| | 2 | Ras-intrinsic-GT
Pase | Ras
Pathway No. 63 | 0.0001
(s^-1) | 0
(s^-1) | - | - | Substrate:
GTP-Ras
Products:
GDP-Ras
| | This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4 | | 3 | dephosph-GAP | Ras
Pathway No. 63 | 0.1
(s^-1) | 0
(s^-1) | - | - | Substrate:
GAP*
Products:
GAP
| | Assume a reasonably good rate for dephosphorylating it, 1/sec |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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