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Enzyme List for pathway IP3-3K (Pathway Number 109)

 Molecule Name/
Site Name 		Km (uM) kcat (1/s)Ratio
(k2/k3)		Enzyme TypeSubstrate Product
1 Enzyme Activity:
ip3-3k

Enzyme Molecule:
IP3_3K		1.43.04754explicit E-S complexIP3(145)
IP4(1345)
  from Johanson et al, JBC 263; 1988 Original Vmax scaled up by 50% to obtain value at 37C, as enzyme assay was done at 30C Km increased from 0.2 to 1.4 as per various other reports (Shears Review, BiochemJ 260; 1989)
2 Enzyme Activity:
ip3-3k*

Enzyme Molecule:
IP3_3K*		1.43.04754explicit E-S complexIP3(145)
IP4(1345)
  from Communi et al, EMBO J 16; 1997 In absence of CaM binding, activity same as that of non-phosphorylated enzyme
3 Enzyme Activity:
ip3-3k*1

Enzyme Molecule:
IP3_3K*1		1.40.76194.00003explicit E-S complexIP3(145)
IP4(1345)
  from Sim et al, JBC 265; 1990
4 Enzyme Activity:
ip3-3k-CaM

Enzyme Molecule:
IP3_3K_CaM		2.800110.54.0001explicit E-S complexIP3(145)
IP4(1345)
  from Erneux et al, Biochem 214; 1993 2-2.5 fold more active than ip3-3k but Km is doubled, hence Vmax adjusted accordingly.
5 Enzyme Activity:
ip3-3k-CaM*

Enzyme Molecule:
IP3_3K_CaM*		2.8454explicit E-S complexIP3(145)
IP4(1345)
  from Communi et al, EMBO J 16; 1997 Vmax adjusted to obtain 9-fold greater activity than ip3-3k
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