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Molecule Parameter List for IP3_3K_CaM*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
IP3_3K_CaM* participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1010201

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • NonOsc_Ca_
    IP3metabolism
  • 23Network
    MIPP CaMKII CaM 
    PKC IP3-3K CaRegulation 
    Gq PLCbeta 134_dephos 
    145_dephos IP4-system IHP-system 
    1345_dephos 
    This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. The calcium response is non-oscillatory. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    IP3_3K_CaM* acting as a Molecule in  
    NonOsc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    IP3_3K_CaM*
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • IP3-3K
    Pathway No. : 109
    01000No
    8-10 fold activation with both CaM bound and CaMKII phosphorylation (phos at thr311) Communi et al; EMBO J 16 (8), pp 1943-1952, 1997

    IP3_3K_CaM* acting as an Enzyme in  
    NonOsc_Ca_IP3metabolism Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    IP3_3K_CaM* /
    ip3-3k-CaM*
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • IP3-3K
    Pathway No. : 109
    2.80002454explicit E-S complexSubstrate
    IP3(145)

    Product
    IP4(1345)
    from Communi et al, EMBO J 16; 1997 Vmax adjusted to obtain 9-fold greater activity than ip3-3k

    IP3_3K_CaM* acting as a Product of an Enzyme in  
    NonOsc_Ca_IP3metabolism Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1tot_CaM_CaMKII  /
    CaM-CaMK-phos1
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • CaMKII
    Pathway No. : 106
    1.599980.54explicit E-S complexSubstrate
    IP3_3K_CaM

    Product
    IP3_3K_CaM*
        rates referred from standard CaM-CaMKII phosphorylation rates
    2
  • tot_autonomous_
    CaMKII
      /
    CaMK-phos1
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • CaMKII
    Pathway No. : 106
    2.499950.54explicit E-S complexSubstrate
    IP3_3K_CaM

    Product
    IP3_3K_CaM*
        rates referred from standard CaMKII phosphorylation rates

    IP3_3K_CaM* acting as a Product in a reaction in  
    NonOsc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    3K*-bind-CaM
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • IP3-3K
    Pathway No. : 109
    49.9998
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 0.002(uM)-Substrate
    CaM-Ca4
    IP3_3K*

    Product
    IP3_3K_CaM*
    Communi et al, EMBO J 16; 1997 phosphorylated 3kinase has 25 fold greater sensitivity to CaM binding than the non-phosphorylated enzyme (Kd of 2nM)



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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