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Enzyme List for pathway 145_dephos (Pathway Number 153)

 Molecule Name/
Site Name 		Km (uM) kcat (1/s)Ratio
(k2/k3)		Enzyme TypeSubstrate Product
1 Enzyme Activity:
ip2_1pase

Enzyme Molecule:
IP_1pase		5.000124explicit E-S complexIP2(14)
IP1(4)
  from Inhorn and Majerus, JBC 1987 Vmax reduced from 5.625 to 2 to maintain levels of IP2(14)
2 Enzyme Activity:
ip3_1pase

Enzyme Molecule:
IP_1pase		20.00214.1254explicit E-S complexIP3(134)
IP2(34)
  Ins(134) 1-phosphatase activity of InsP 1-phosphatase from Inhorn and Majerus, JBC 262; 1987
3 Enzyme Activity:
ip3_5pase1

Enzyme Molecule:
IP_5pase1		31.14explicit E-S complexIP3(145)
IP2(14)
  Ins(145)P3 5-phosphatase activity of InsP-5-phosphatase from Hansen et al, JBC 262; 1987
4 Enzyme Activity:
ip3_5pase2

Enzyme Molecule:
IP3_5pase2		18.000410.6673.99991explicit E-S complexIP3(145)
IP2(14)
  from Hansen et al, JBC 262, 1987 activity determined from pH curve. Value scaled 1.5 times to obtain activity at 37C as original experiment was performed at 30C
5 Enzyme Activity:
ip4_5pase

Enzyme Molecule:
IP_5pase1		0.80.094explicit E-S complexIP4(1345)
IP3(134)
  Ins(1345)P4 5-phosphatase activity of InsP 5-phosphatase1 from Hansen et al, JBC 262; 1987 vmax for IP4 substrate is approx 0.1 times vmax for IP3
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