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Reaction List for pathway IP3-3K (Pathway Number 109) |
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered. |
| Name | Kf | Kb | Kd | tau | Substrate | Product | |
| 1 | 3K*-bind-CaM | 49.9998 (uM^-1 s^-1) | 0.1 (s^-1) | Kd(bf) = 0.002(uM) | - | IP3_3K* CaM-Ca4 | IP3_3K_CaM* |
| Communi et al, EMBO J 16; 1997 phosphorylated 3kinase has 25 fold greater sensitivity to CaM binding than the non-phosphorylated enzyme (Kd of 2nM) | |||||||
| 2 | 3K-bind-CaM | 19.2312 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.052(uM) | - | IP3_3K CaM-Ca4 | IP3_3K_CaM |
| Communi et al, EMBO J 16; 1997 non-phosphorylated 3kinase with low sensitivity to CaM binding (Kd = 52nM) | |||||||
| Pathway Detail | Molecule List | Enzyme List | Reaction List |