 |  |  PKA |
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Reaction List for pathway PLA2 (Pathway Number 349) | | Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered. |
| | Name | Kf | Kb | Kd | tau | Substrate | Product | | 1 |
DAG-Ca-PLA2-act | 0.003
(uM^-1 s^-1) | 4
(s^-1) | Kd(bf) = 1333.3467(uM) | - | DAG
PLA2-Ca*
| DAG-Ca-PLA2*
| | | 27 June 1996 Scaled kf down by 0.015 from 3.33e-7 to 5e-9 to fit with revised DAG estimates and use of mole-fraction to calculate eff on PLA2. | | 2 |
Degrade-AA | 0.4
(s^-1) | 0
(s^-1) | - | - | AA
| APC
| | | I need to check if the AA degradation pathway really leads back to APC. Anyway, it is a convenient buffered pool to dump it back into. For the purposes of the full model we use a rate of degradation of 0.2/sec Raised decay to 0.4 : see PLA35.g notes for Feb17 | | 3 |
dephosphorylate-
PLA2* | 0.17
(s^-1) | 0
(s^-1) | - | - | PLA2*
| PLA2-cytosolic
| | 4 |
PIP2-Ca-PLA2-act | 0.012
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 8.3335(uM) | - | temp-PIP2
PLA2-Ca*
| PIP2-Ca-PLA2*
| | 5 |
PIP2-PLA2-act | 0.0012
(uM^-1 s^-1) | 0.5
(s^-1) | Kd(bf) = 416.6771(uM) | - | temp-PIP2
PLA2-cytosolic
| PIP2-PLA2*
| | 6 |
PLA2*-Ca-act | 6
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0167(uM) | - | PLA2*
Ca
| PLA2*-Ca
| | | To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien.... | | 7 |
PLA2-Ca-act | 1
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.1(uM) | - | PLA2-cytosolic
Ca
| PLA2-Ca*
| | | Leslie and Channon BBA 1045 (1990) 261-270 fig6 pp267. |
Pathway Details Molecule List Enzyme List Reaction List
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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