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Parameters for L-Arginine (Pathway Number 308)

Pathway Layout

Pathway Basic Parameters

Pathway NameL-Arginine
Pathway Entry Number 308
Accession Number 72
Accession Name L-Arginine
Species Human
Tissue Kidney cell expressing the rat brain nNOS
CellCompartmentCytosol
Related Pathways
Notes This model was taken from the Abu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51. This model shows kinetic binding of L-Arginine to neuronal nitric oxide synthase.
Model shows the substrate (L-Arginine) binding to nNOS in a two-step reversible fashion. First there is rapid binding equilibrium between Im-nNOS and L-Arginine to form an intermediate that contains bound imidazole and L-Arginine. This is followed by a slower conformational change in the Im-enzyme-substrate complex that is associated with release of bound imidazole and generation of a modified enzyme-substrate complex which is detected due to spectral change. Replicates Figure 4 (right panel).

Statistics

Enzyme sites
5
0
2

Conversion format

This pathway is part of accession 72 and is completely specified in the file acc72.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc72.g   
MATLAB format    acc72.m   
SBML format    acc72.xml   
Pathway DetailMolecule ListEnzyme ListReaction List