NCBS Home page
Accession List
Pathway List
Search
Authorized Users
Help
News archives

Accession Type:
Pathway
L-Arginine
L-Arginine

Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.
Search in: Search for Match By

Accession information for L-Arginine (Accession Number 72)

Reaction Scheme

Accession Basic Parameters

Name L-Arginine
Accession Type Pathway
Transcriber Sharat J. Vayttaden and Prasoon Agarwal, NCBS
Developer Abu-Soud HM, Wang J, Rousseau DL, and Stuehr DJ
Entry Date (YYYY-MM-DD) 2006-08-07 00:00:00
Species Human
Tissue Kidney cell expressing the rat brain nNOS
Cell Compartment Cytosol
Source Abu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51. ( Peer-reviewed publication )
Methodology Quantitative match to experiments
Model Implementation Exact GENESIS implementation
Model Validation Approximates original data
Notes This model was taken from the Abu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51. This model shows kinetic binding of L-Arginine to neuronal nitric oxide synthase.
Model shows the substrate (L-Arginine) binding to nNOS in a two-step reversible fashion. First there is rapid binding equilibrium between Im-nNOS and L-Arginine to form an intermediate that contains bound imidazole and L-Arginine. This is followed by a slower conformational change in the Im-enzyme-substrate complex that is associated with release of bound imidazole and generation of a modified enzyme-substrate complex which is detected due to spectral change. Replicates Figure 4 (right panel).

Conversion formats

FormatFile
Native Format (GENESIS format)    acc72.g   
MATLAB format    acc72.m   
SBML format    acc72.xml   



Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.