|
Enter a Search String | | Special character and space not allowed in the query term.
Search string should be at least 2 characters long. |
Molecule List for pathway PLA2 (Pathway Number 349) in Accession Ajay_Bhalla_2004_Feedback_Tuning (Accession Number 78) | Default ordering is done according to Pathway Number. Table headers can be used for changing the default ordering.
  arrow indicates that ordering is done according to ascending or descending order.
The entries are grouped according to Pathway Number and are alternately color coded using  and  color. |
| |
Name | Accession
Type | Initial
Conc.
(uM) | Volume
(fL) | Buffered | Sum Total Of | | 1 | APC | Network | 30 | 0 | Yes | - | | | arachodonylphosphatidylcholine is the favoured substrate from Wijkander and Sundler, JBC 202 pp 873-880, 1991. Their assay used 30 uM substrate, which is what the kinetics in this model are based on. For the later model we should locate a more realistic value for APC. | | 2 | DAG-Ca-PLA2* | Network | 0 | 0 | No | - | | 3 | PIP2-Ca-PLA2* | Network | 0 | 0 | No | - | | 4 | PIP2-PLA2* | Network | 0 | 0 | No | - | | 5 | PLA2* | Network | 0 | 0 | No | - | | 6 | PLA2*-Ca | Network | 0 | 0 | No | - | | | Phosphorylated form of PLA2. Still need to hook it up using kinases. PKA: Wightman et al JBC 257 pp6650 1982 PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone Do not know if there is a Ca requirement for active phosphorylated state. | | 7 | PLA2-Ca* | Network | 0 | 0 | No | - | | 8 | PLA2-cytosolic | Network | 0.4 | 0 | No | - | | | Calculated cytosolic was 20 nm from Wijkander and Sundler However, Leslie and Channon use about 400 nM. Need to confirm, but this is the value I use here. Another recalc of W&S gives 1uM |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
|
