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Molecule Parameter List for MIPP

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
MIPP participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1030000

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • NonOsc_Ca_
    IP3metabolism
  • 31Network
    MIPP CaMKII CaM 
    PKC IP3-3K CaRegulation 
    Gq PLCbeta 134_dephos 
    145_dephos IP4-system IHP-system 
    1345_dephos 
    This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. It is similar to the NonOsc_Ca_IP3metab model (accession 23) except that some enzymes have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. These modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    MIPP acting as a Molecule in  
    NonOsc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    MIPP
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • MIPP
    Pathway No. : 144
    0.398160No
    Multiple Inositol Polyphosphate Phosphatase from Nogimori et al, JBC 266(25); 1991: 16499-506 MIPP clustered in ER. Distinct transporters present for cytosolic substrates. Accounts for 30-45% of total 3-phosphatase activity against substrates, hence cytosolic counterparts of this enzyme must be present (as per Chi et al, MCB 20; 2000: 6496-507)

    MIPP acting as an Enzyme in  
    NonOsc_Ca_IP3metabolism Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1MIPP /
    ip5_3pase
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • MIPP
    Pathway No. : 144
    0.04000050.23214explicit E-S complexSubstrate
    IP5(13456)_ER

    Product
    IP4(1456)_ER
        Ins(13456)P5 3-phosphatase from Nogimori et al, JBC 266; 1991
    2MIPP /
    ip4_3pase
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • MIPP
    Pathway No. : 144
    0.134.6754explicit E-S complexSubstrate
    IP4(1345)_ER

    Product
    IP3(145)_ER
        Ins(1345)P4 3-phosphatase from Nogimori et al, JBC 266; 1991
    3MIPP /
    ip6_pase
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • MIPP
    Pathway No. : 144
    0.0002999960.01324explicit E-S complexSubstrate
    IP6_ER

    Product
    IP5(12456)_ER
    IP5(13456)_ER
        InsP6 2/3-phosphatase from Nogimori et al, JBC 266; 1991



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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