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Molecule Parameter List for Ca-sequester

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
Ca-sequester participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000091

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • NonOsc_Ca_
    IP3metabolism
  • 31Network
    MIPP CaMKII CaM 
    PKC IP3-3K CaRegulation 
    Gq PLCbeta 134_dephos 
    145_dephos IP4-system IHP-system 
    1345_dephos 
    This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. It is similar to the NonOsc_Ca_IP3metab model (accession 23) except that some enzymes have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. These modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    Ca-sequester acting as a Molecule in  
    NonOsc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    Ca-sequester
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • CaRegulation
    Pathway No. : 149
    5.796160No
    Sequestered Ca pool The vol is 0.16 * the vol of the cell as a whole.

    Ca-sequester acting as a Substrate in a reaction in  
    NonOsc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1Ca5-bind-Cal
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • CaRegulation
    Pathway No. : 149
    0.0005
    (uM^-5 s^-1)
    1
    (s^-1)
    --Substrate
    Ca-sequester
    Ca-sequester
    Ca-sequester
    Ca-sequester
    Ca-sequester
    Calseq

    Product
    Ca5-Cal
      There are actually 5 Ca-sequester substrates for this reaction, along with one Calseq. Due to system limitations only four are entered.
    2
  • inactivate_cap_
    Ca
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • CaRegulation
    Pathway No. : 149
    0
    (#^-2 s^-1)
    1
    (s^-1)
    Not applicable**-Substrate
    Ca-sequester
    Ca-sequester
  • capacitive_Ca_
    entry*


    Product
    inact_cap_entry
  •   The Kd is set at about 3 uM so that at resting Ca the capacitative Ca entry is almost blocked. A 2nd order response makes the response steep.
    3Ca10-bind-Cal
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • CaRegulation
    Pathway No. : 149
    0.0005
    (uM^-5 s^-1)
    1
    (s^-1)
    --Substrate
    Ca-sequester
    Ca-sequester
    Ca-sequester
    Ca-sequester
    Ca-sequester
    Ca5-Cal

    Product
    Ca10-Cal
      There are actually 5 Ca-sequester substrates for this reaction, along with Ca5-Cal. Due to system limitations only four are entered.
    4Ca15-bind-Cal
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • CaRegulation
    Pathway No. : 149
    0.0005
    (uM^-5 s^-1)
    1
    (s^-1)
    --Substrate
    Ca-sequester
    Ca-sequester
    Ca-sequester
    Ca-sequester
    Ca-sequester
    Ca10-Cal

    Product
    Ca15-Cal
      There are actually 5 Ca-sequester substrates for this reaction, along with Ca10-Cal. Due to system limitations only four are entered.
    5Ca20-bind-Cal
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • CaRegulation
    Pathway No. : 149
    0.0005
    (uM^-5 s^-1)
    1
    (s^-1)
    --Substrate
    Ca-sequester
    Ca-sequester
    Ca-sequester
    Ca-sequester
    Ca-sequester
    Ca15-Cal

    Product
    Ca20-Cal
      There are actually 5 Ca-sequester substrates for this reaction, along with Ca15-Cal. Due to system limitations only four are entered.
    6Ca25-bind-Cal
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • CaRegulation
    Pathway No. : 149
    0.0005
    (uM^-5 s^-1)
    1
    (s^-1)
    --Substrate
    Ca-sequester
    Ca-sequester
    Ca-sequester
    Ca-sequester
    Ca-sequester
    Ca20-Cal

    Product
    Ca25-Cal
      There are actually 5 Ca-sequester substrates for this reaction, along with Ca20-Cal. Due to system limitations only four are entered.
    7Ca30-bind-Cal
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • CaRegulation
    Pathway No. : 149
    0.0005
    (uM^-5 s^-1)
    1
    (s^-1)
    --Substrate
    Ca-sequester
    Ca-sequester
    Ca-sequester
    Ca-sequester
    Ca-sequester
    Ca25-Cal

    Product
    Ca30-Cal
      There are actually 5 Ca-sequester substrates for this reaction, along with Ca25-Cal. Due to system limitations only four are entered.
    8Ca35-bind-Cal
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • CaRegulation
    Pathway No. : 149
    0.0005
    (uM^-5 s^-1)
    1
    (s^-1)
    --Substrate
    Ca-sequester
    Ca-sequester
    Ca-sequester
    Ca-sequester
    Ca-sequester
    Ca30-Cal

    Product
    Ca35-Cal
      There are actually 5 Ca-sequester substrates for this reaction, along with Ca30-Cal. Due to system limitations only four are entered.
    9Ca40-bind-Cal
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • CaRegulation
    Pathway No. : 149
    0.0005
    (uM^-5 s^-1)
    1
    (s^-1)
    --Substrate
    Ca-sequester
    Ca-sequester
    Ca-sequester
    Ca-sequester
    Ca-sequester
    Ca35-Cal

    Product
    Ca40-Cal
      There are actually 5 Ca-sequester substrates for this reaction, along with Ca35-Cal. Due to system limitations only four are entered.

    Ca-sequester acting as a Product in a reaction in  
    NonOsc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    CaTraspATPase
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • CaRegulation
    Pathway No. : 149
    25
    (s^-1)
    0
    (#^-2 s^-1)
    Not applicable**-Substrate
    CaTransp-2Ca

    Product
    Ca-sequester
    Ca-sequester
    CaTransp
    kCa3 = 2 * Ca transporter rate since each step has 2 Ca++. = 0.5 uM/sec from Lauffenburger and Linderman 1993 Receptors pg200 The amount of the activated transporter is about 0.01 uM = 6e3#. from runs. So 0.01uM * kf * 2 = 0.5 uM/sec (no back reaction) so kf = 25, kb = 0 Alternatively, 6e3 * kf = 0.25 * 6e5, giving the same kf
    ** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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