NCBS Home page
Accession List
Pathway List
Search
Authorized Users
Help
News archives

Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.
Search in: Search for Match By

Molecule Parameter List for IP_4pase

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
IP_4pase participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1020010

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • NonOsc_Ca_
    IP3metabolism
  • 31Network
    MIPP CaMKII CaM 
    PKC IP3-3K CaRegulation 
    Gq PLCbeta 134_dephos 
    145_dephos IP4-system IHP-system 
    1345_dephos 
    This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. It is similar to the NonOsc_Ca_IP3metab model (accession 23) except that some enzymes have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. These modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    IP_4pase acting as a Molecule in  
    NonOsc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    IP_4pase
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • 134_dephos
    Pathway No. : 152
    0.91000No
    from Norris et al, JBC 269(12); 1994: 8716-20 Enzyme conc increased from 9 nM to 0.9 uM to obtain appreciable enzyme activity has two 4-phosphatase activities: against Ins(134)P3 and Ins(34)P2 respectively

    IP_4pase acting as an Enzyme in  
    NonOsc_Ca_IP3metabolism Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1IP_4pase /
    ip3_4pase
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • 134_dephos
    Pathway No. : 152
    20.0014204explicit E-S complexSubstrate
    IP3(134)

    Product
    IP2(13)
        Ins(134)P3 4-phosphatase activity of InsP 4-phosphatase from Norris et al, JBC 269; 1994. Vmax reduced from 55/sec to 20/sec to maintain relative levels of Ins(134)P3 and Ins(13)P2
    2IP_4pase /
    ip2_4pase
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • 134_dephos
    Pathway No. : 152
    22.9995554explicit E-S complexSubstrate
    IP2(34)

    Product
    IP1(3)
        Ins(34)P2 4-phosphatase activity of InsP 4-phosphatase from Norris et al, JBC 269; 1994

    IP_4pase acting as a Substrate in a reaction in  
    NonOsc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    IP_4pase-inact
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • 134_dephos
    Pathway No. : 152
    1
    (uM^-1 s^-1)
    19
    (s^-1)
    Kd(bf) = 19(uM)-Substrate
    IP6
    IP_4pase

    Product
    IP_4pase_inact
    from Norris et al, JBC 269; 1994



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.