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Molecule Parameter List for IP4(1346)

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
IP4(1346) participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000011

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • NonOsc_Ca_
    IP3metabolism
  • 31Network
    MIPP CaMKII CaM 
    PKC IP3-3K CaRegulation 
    Gq PLCbeta 134_dephos 
    145_dephos IP4-system IHP-system 
    1345_dephos 
    This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. It is similar to the NonOsc_Ca_IP3metab model (accession 23) except that some enzymes have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. These modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    IP4(1346) acting as a Molecule in  
    NonOsc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    IP4(1346)
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IP4-system
    Pathway No. : 154
    11000No
    Inositol (1346)tetrakisphosphate

    IP4(1346) acting as a Substrate in a reaction in  
    NonOsc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    ip4-5K
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IP4-system
    Pathway No. : 154
    0.15
    (s^-1)
    0.003
    (s^-1)
    Keq = 0.02(uM)6.536secSubstrate
    IP4(1346)

    Product
    IP5(13456)
    Kf based on basal levels of Ins(1346)P4 Kb obtained from dG calculations for equilibrium product substrate conditions.

    IP4(1346) acting as a Product in a reaction in  
    NonOsc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    6kinase
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IP4-system
    Pathway No. : 154
    0.256
    (s^-1)
    0
    (uM^-1 s^-1)
    --Substrate
    IP3-56Kcmplx

    Product
    IP3-56K_IP4-1K
    IP4(1346)
    Kf = Vmax for IP3 56-K from Yang and Shears, Biochem J 2000; 351:551-555 Enzyme reversibility reported in Ho et al, Curr Biol 2002, 12: 1-20. But backflow calculations do not show that Kb needs to be incorporated



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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