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Molecule Parameter List for ip4_3k_cmplx

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
ip4_3k_cmplx participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000011

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • NonOsc_Ca_
    IP3metabolism
  • 31Network
    MIPP CaMKII CaM 
    PKC IP3-3K CaRegulation 
    Gq PLCbeta 134_dephos 
    145_dephos IP4-system IHP-system 
    1345_dephos 
    This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. It is similar to the NonOsc_Ca_IP3metab model (accession 23) except that some enzymes have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. These modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    ip4_3k_cmplx acting as a Molecule in  
    NonOsc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    ip4_3k_cmplx
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IP4-system
    Pathway No. : 154
    01000No
    Enzyme complex exclusively modeled to include reversible kinetics, as the back flux is significant for dG = -10 kJ/mol

    ip4_3k_cmplx acting as a Substrate in a reaction in  
    NonOsc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    ip4-3k-off
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IP4-system
    Pathway No. : 154
    4.3
    (s^-1)
    0.2687
    (uM^-1 s^-1)
    Kd(cb) = 0.0625(uM)-Substrate
    ip4_3k_cmplx

    Product
    IP4-3K
    IP5(13456)
    Kf = Vmax for enzyme: Stephens et al, Biochem J 249; 1988. Kb ascertained from dG calculations for equilibrium conditions.

    ip4_3k_cmplx acting as a Product in a reaction in  
    NonOsc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    ip4-3k-on
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 31
  • IP4-system
    Pathway No. : 154
    53.7501
    (uM^-1 s^-1)
    17.2
    (s^-1)
    Kd(bf) = 0.32(uM)-Substrate
    IP4(1456)
    IP4-3K

    Product
    ip4_3k_cmplx
    Rates derived from Km for enzyme: Stephens et al, Biochem J 249; 1988.



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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