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Molecule Parameter List for IP2(13)

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
IP2(13) participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1002100

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Osc_Ca_
    IP3metabolism
  • 32Network
    MIPP CaMKII CaM 
    PKC IP3-3K Gq 
    PLCbeta 134_dephos 145_dephos 
    IP4-system IHP-system 1345_dephos 
    CaRegulation Othmer-Tang-model 
    This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It is similar to the Osc_Ca_IP3metab model (accession 24) except that some enzymes in the InsP3 metabolism network have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. The modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    IP2(13) acting as a Molecule in  
    Osc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    IP2(13)
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • 134_dephos
    Pathway No. : 165
    01000No
    Inositol (13)bisphosphate

    IP2(13) acting as a Substrate for an Enzyme in  
    Osc_Ca_IP3metabolism Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1IP2_3pase2  /
    ip2_3pase2
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • 134_dephos
    Pathway No. : 165
    3.7000139.24explicit E-S complexSubstrate
    IP2(13)

    Product
    IP1(1)
        from Caldwell et al, JBC 266; 1991
    2IP2_3pase1  /
    ip2_3pase1
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • 134_dephos
    Pathway No. : 165
    0.799992117.334explicit E-S complexSubstrate
    IP2(13)

    Product
    IP1(1)
        from Caldwell et al, JBC 266; 1991 enzyme activity was assayed for the monomeric form of the enzyme

    IP2(13) acting as a Product of an Enzyme in  
    Osc_Ca_IP3metabolism Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    IP_4pase  /
    ip3_4pase
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • 134_dephos
    Pathway No. : 165
    20.0014204explicit E-S complexSubstrate
    IP3(134)

    Product
    IP2(13)
    Ins(134)P3 4-phosphatase activity of InsP 4-phosphatase from Norris et al, JBC 269; 1994. Vmax reduced from 55/sec to 20/sec to maintain relative levels of Ins(134)P3 and Ins(13)P2



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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