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Molecule Parameter List for IP3R

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
IP3R participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000010

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Osc_Ca_
    IP3metabolism
  • 32Network
    MIPP CaMKII CaM 
    PKC IP3-3K Gq 
    PLCbeta 134_dephos 145_dephos 
    IP4-system IHP-system 1345_dephos 
    CaRegulation Othmer-Tang-model 
    This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It is similar to the Osc_Ca_IP3metab model (accession 24) except that some enzymes in the InsP3 metabolism network have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. The modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    IP3R acting as a Molecule in  
    Osc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    IP3R
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • Othmer-Tang-mode
    l

    Pathway No. : 171
  • 0.11000No
    IP3 Receptor with no ligand bound

    IP3R acting as a Substrate in a reaction in  
    Osc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    bind_IP3
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • Othmer-Tang-mode
    l

    Pathway No. : 171
  • 12
    (uM^-1 s^-1)
    8
    (s^-1)
    Kd(bf) = 0.6667(uM)-Substrate
    IP3
    IP3R

    Product
    IP3.IP3R
    from the O-T model in Tang et al, Biophys J 70, 1996



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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