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Molecule Parameter List for Ca-ext | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| Ca-ext participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Osc_Ca_
IP3metabolism | 32 | Network |
MIPP, CaMKII, CaM,
PKC, IP3-3K, Gq,
PLCbeta, 134_dephos, 145_dephos,
IP4-system, IHP-system, 1345_dephos,
CaRegulation, Othmer-Tang-model | | This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It is similar to the Osc_Ca_IP3metab model (accession 24) except that some enzymes in the InsP3 metabolism network have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. The modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. |
Ca-ext acting as a Molecule in Osc_Ca_IP3metabolism Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | Ca-ext | Osc_Ca_
IP3metabolism
Accession No. : 32 | CaRegulation
Pathway No. : 170 | 4000 | 100000 | Yes | | Extracell Ca conc = 4 mM Extracell vol assumed 100 X cell vol. It is anyway kept buffered for the purposes of the model, so the concentration won't change. |
Ca-ext acting as a Product of an Enzyme in Osc_Ca_IP3metabolism Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | CaEPump /
Ca-pump-out | Osc_Ca_
IP3metabolism
Accession No. : 32 | CaRegulation
Pathway No. : 170 | 0.0899977 | 200 | 4 | explicit E-S complex | Substrate
Ca
Product
Ca-ext
| | Both affinity and Vmax of the Ca-pump are higher than those used in the model that generates non-oscillatory Ca dynamics. Km has been decreased from 0.2 to 0.09 uM and Vmax increased from 72 to 200. The parameters are constrained by the need to generate Ca oscillations by the Othmer-Tang model. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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