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Molecule Parameter List for Rec-Gq

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
Rec-Gq participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000021

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig4_synapse3Network
Shared_Object_fig4_synapse PKC PLA2 
PLCbeta Gq MAPK 
Ras CaMKII CaM 
PP1 PP2B PKA 
AC 
This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper.
Demonstration script files for generating the figures in the paper, including figure 4, are available here.

Rec-Gq acting as a Molecule in  
fig4_synapse Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
Rec-Gqfig4_synapse
Accession No. : 3
Gq
Pathway No. : 23
01000No

Rec-Gq acting as a Substrate in a reaction in  
fig4_synapse Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
 NameAccession NamePathway NameKfKbKdtauReagents
1Glu-bind-Rec-Gqfig4_synapse
Accession No. : 3
Gq
Pathway No. : 23
16.8
(uM^-1 s^-1)
0.1
(s^-1)
Kd(bf) = 0.006(uM)-Substrate
Glu
Rec-Gq

Product
Rec-Glu-Gq
2
  • Antag-bind-Rec-G
    q
  • fig4_synapse
    Accession No. : 3
    Gq
    Pathway No. : 23
    60
    (uM^-1 s^-1)
    0.01
    (s^-1)
    Kd(bf) = 0.0002(uM)-Substrate
    Rec-Gq
    mGluRAntag

    Product
    Blocked-rec-Gq

    Rec-Gq acting as a Product in a reaction in  
    fig4_synapse Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    Rec-bind-Gqfig4_synapse
    Accession No. : 3
    Gq
    Pathway No. : 23
    0.6
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 1.6667(uM)-Substrate
    G-GDP
    mGluR

    Product
    Rec-Gq



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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