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Molecule Parameter List for PP1-I1*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PP1-I1* participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences2004002

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • AMPAR_traff_
    model0
  • 59Network
    Shared_Object_AMPAR_traff_model0 CaMKII CaM 
    PP1 PP2B PP1_PSD 
    PKA AC AMPAR 
    AMPAR_memb 
    This is model 0 from Hayer and Bhalla, PLoS Comput Biol 2005. It has a bistable model of AMPAR traffick, plus a non-bistable model of CaMKII. This differs from the reference model (model 1) in that model0 lacks degradation and turno ver reactions for AMPAR.

    PP1-I1* acting as a Molecule in  
    AMPAR_traff_model0 Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    PP1-I1*
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PP1
    Pathway No. : 237
    00.09No
    PP1-I1*
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PP1_PSD
    Pathway No. : 239
    00.01No

    PP1-I1* acting as a Substrate for an Enzyme in  
    AMPAR_traff_model0 Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1PP2A  /
  • PP2A-dephosph-PP
    1-I*
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PP1
    Pathway No. : 237
    15.999924.1667explicit E-S complexSubstrate
    PP1-I1*

    Product
    PP1-I1
        k1 changed from 3.3e-6 to 6.6e-6
    2PP2A  /

  • PP2A-dephosph-PP
    1-I*_
    PSD
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PP1
    Pathway No. : 237
    15.999924.1667explicit E-S complexSubstrate
    PP1-I1*

    Product
    PP1-I1
        k1 changed from 3.3e-6 to 6.6e-6
    3CaM_Ca_n-CaNAB  /
    dephosph-PP1-I*
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PP2B
    Pathway No. : 238
    4.970790.344explicit E-S complexSubstrate
    PP1-I1*

    Product
    PP1-I1
    4CaM_Ca_n-CaNAB  /

  • dephosph-PP1-I*_
    PSD
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PP2B
    Pathway No. : 238
    4.970710.344explicit E-S complexSubstrate
    PP1-I1*

    Product
    PP1-I1

    PP1-I1* acting as a Product in a reaction in  
    AMPAR_traff_model0 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1Inact-PP1
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PP1
    Pathway No. : 237
    499.981
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 0.0002(uM)-Substrate
    I1*
    PP1-active

    Product
    PP1-I1*
      K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4
    2Inact-PP1
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PP1_PSD
    Pathway No. : 239
    499.98
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 0.0002(uM)-Substrate
    I1*
    PP1-active_PSD

    Product
    PP1-I1*
      K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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